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Literature DB >> 2274105

GABA-gated chloride ion influx in brains of epileptic El mice.

M Ito¹, H Tsuda, K Oguro, K Mutoh, H Shiraishi, Y Shirasaka, H Mikawa.

Abstract

GABA-gated chloride ion influx was measured in brain "microsac" preparations of epileptic El mice. There was significantly greater sensitivity to GABA in stimulated El mice (which had 14-18 convulsions induced at weekly intervals) than in unstimulated El mice (which had not experienced convulsions) or ddY mice. GABA-gated chloride ion influx was significantly decreased 20 min after a single convulsion, and returned to the preconvulsion level 60 min after a convulsion. These findings suggest that the functional state of GABA-gated chloride channel in El mice is changed secondarily by single or repeated convulsions.

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Year: 1990 PMID： 2274105 DOI： 10.1007/bf00965915

Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996

14 in total

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Journal: Adv Neurol Date: 1975

2. Involvement of the noradrenergic system in the seizures of epileptic El mice.

Authors: H Tsuda; M Ito; K Oguro; K Mutoh; H Shiraishi; Y Shirasaka; H Mikawa
Journal: Eur J Pharmacol Date: 1990-02-13 Impact factor: 4.432

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Authors: J Ochi; M Ito; T Okuno; H Mikawa
Journal: Epilepsia Date: 1988 Jan-Feb Impact factor: 5.864

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Journal: J Neurochem Date: 1981-07 Impact factor: 5.372

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Authors: R H Thalmann; N Hershkowitz
Journal: Brain Res Date: 1985-09-09 Impact factor: 3.252

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Authors: R N McBurney; J L Barker
Journal: Nature Date: 1978-08-10 Impact factor: 49.962

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Authors: A Nistri; A Constanti; K Krnjević
Journal: Adv Biochem Psychopharmacol Date: 1980

8. gamma-Aminobutyric acid, benzodiazepine binding sites and gamma-aminobutyric acid concentrations in epileptic E1 mouse brain.

Authors: H Hattori; M Ito; H Mikawa
Journal: Eur J Pharmacol Date: 1985-12-17 Impact factor: 4.432

9. Decreased benzodiazepine receptor binding in epileptic El mice: a quantitative autoradiographic study.

Authors: Y Shirasaka; M Ito; H Tsuda; H Shiraishi; K Oguro; K Mutoh; H Mikawa
Journal: Neurochem Res Date: 1990-09 Impact factor: 3.996

10. gamma-Aminobutyric acid agonists and antagonists alter chloride flux across brain membranes.

Authors: A M Allan; R A Harris
Journal: Mol Pharmacol Date: 1986-05 Impact factor: 4.436

5 in total

1. Down-regulation of S-adenosylhomocysteine hydrolase in the active methyl transfer system in the brain of genetically epileptic El mice.

Authors: O Ohmori; H Hirano; T Ono; K Abe; T Mita
Journal: Neurochem Res Date: 1996-10 Impact factor: 3.996

5. Evaluation of the possible epileptogenic activity of ciprofloxacin: the role of Nigella sativa on amino acids neurotransmitters.

Authors: Nadia M S Arafa; Mona Abdel-Rahman; Manal F El-khadragy; Rami B Kassab
Journal: Neurochem Res Date: 2012-10-21 Impact factor: 3.996