Sensory Loss Mimicking Cauda Equina Syndrome due to Cervical Spinal Lesion in a Patient with Clinically Isolated Syndrome.

We describe the case of a 39-year-old woman with signs and symptoms suggesting cauda equina syndrome. Lumbosacral magnetic resonance imaging (MRI) demonstrated no lesion at this level, while cervical MRI showed a T2-hyperintense lesion in the middle-right anterolateral region of the cervical spinal cord, which may explain the symptoms by involving the anterior spinothalamic tract. We suggest that in cases with cauda equina syndrome presentation and normal lumbosacral MRI, a cervicodorsal lesion should be considered during diagnostic assessment.

Introduction

Cauda equina syndrome (CES) is a complex clinical entity due to compression of lumbosacral spinal nerve roots encompassed in the dural sac. The fully developed syndrome is characterized by multiple sensory signs and symptoms, including low back pain, saddle hypoesthesia or anesthesia, weakness of the lower extremities and impaired low reflexes, as well as sphincter dysfunction and sexual impotence [1]. The clinical picture of CES may be asymmetric and can substantially differ in each patient, with various combinations of signs and symptoms, often presenting as partial disease onset. CES etiology includes compressive causes, either structural or neoplastic, but also non-compressive causes (ischemic, inflammatory or infectious) [1, 2]. Among compressive causes, lumbosacral disc prolapse is predominant in frequency compared to spinal neoplasms and spinal stenosis, accounting for 45, 29, and 21% of all cases, respectively [2]. Despite the wide range of these causative conditions, the majority of them share a common localization at the lumbosacral level. We present the case of a woman with a clinical picture suggesting CES whose etiology could be assigned to a cervical spinal cord lesion.

Case Report

A 39-year-old woman presented with a three-day history of paresthesias in the saddle region, posterior thighs, legs and soles, mainly on the left side. She also complained of sensory loss at the perineal level, but denied urinary retention or urgency. Neurological examination showed only mild hypoesthesia in the perianal and perigenital regions, especially on the left. Lumbosacral magnetic resonance imaging (MRI) was performed, revealing no lesion at this level (fig. ). Pelvis CT scans were also normal. The electrophysiological assessment showed delayed conduction of the somatosensorial pathway at somatosensory evoked potentials for stimulus applied to the left leg. Routine laboratory tests, including inflammation indexes, autoimmune and neoplastic laboratory assays, were within the normal range. Cerebrospinal fluid (CSF) examination revealed a cell count of 13 cells/mm3, mainly lymphocytes, while CSF total protein content was normal. Abundant oligoclonal IgG bands and intrathecal IgG synthesis were also detected. Blood-brain barrier damage was absent. Serum and CSF antibodies to Borrelia burgdorferi and Treponema pallidum were negative, as were CSF culture for bacteria and fungi and PCR assays for an extensive virus panel. Cervical MRI showed a T2-hyperintense lesion in the middle-right anterolateral region of the cervical (C2) spinal cord (fig. ). Subcortical lesions were also present. This episode was considered a clinically isolated syndrome suggestive of multiple sclerosis, and a high dose of intravenous methylprednisolone was administered. Complete clinical recovery followed, and one month later brain and cervical MRI revealed a considerable improvement in cervical MRI with size reduction of the previously detected lesion. One year later no relapses occurred; no new lesions were detected at neuroimaging during follow-up.

Discussion

As previously mentioned, all potential organic explanations for a clinical picture suggestive of CES are typically searched for within the lumbosacral portion of the spine, and lumbar spine MRI is currently the method of choice to visualize and investigate cauda equina nerve roots within the thecal sac, as suggested by the limited available literature which identified lumbosacral MRI scans as gold standard for CES diagnosis [3, 4, 5]. However, in some cases CES patients may have normal lumbosacral MRI (around 50% of cases), as well as no other clear organic causes of CES, leading to an assumption of a ‘functional’ origin of the clinical findings [4]. The present observations suggest the possibility to consider a cervicodorsal lesion during diagnostic assessment in cases of CES with normal lumbosacral MRI, variability of spinal cord lesion localization being an important point to consider given the somatotopic organization of the spinothalamic sensory fibers (fig. 2c). Indeed, we cannot rule out that the lesion found in this particular case is an incidental finding, but the MRI improvement detected one month later points to a temporal relation between the symptoms and the cervical lesion, which in our case may actually explain the clinical picture mimicking CES. Moreover, bowel, bladder and sexual dysfuntion, which are part of the fully developed CES, were missing in our case, as expected since the relevant afferent and efferent neural circuits are located at the lumbosacral level of the spine. In conclusion, we suggest that in cases presenting with CES symptoms and normal lumbosacral MRI, a cervicodorsal lesion should be considered during diagnostic assessment.

Fig. 2

Sagittal (a) and axial (b) T2-weighted MRI: cervical lesion (C2) in the middle-right anterolateral region. c Somatotopic organization of the anterior spinothalamic tract: sacral sensory projections (S) localize anteriorly to lumbar (L), thoracic (T) and cervical (C) ones, which join posteriorly.

Disclosure Statement

The authors have no conflicts of interest to disclose.