BACKGROUND: A targeted vaccination programme for pandemic H1N1 2009 influenza was introduced in Scotland, UK, in October, 2009. We sought to assess the effectiveness of this vaccine in a sample of the Scottish population during the 2009-10 pandemic. METHODS: We assessed the effectiveness of the Scottish pandemic H1N1 2009 influenza vaccination with a retrospective cohort design. We linked data of patient-level primary care, hospital records, death certification, and virological swabs to construct our cohort. We estimated vaccine effectiveness in a nationally representative sample of the Scottish population by establishing the risk of hospital admission and death (adjusted for potential confounders) resulting from influenza-related morbidity in vaccinated and unvaccinated patients and laboratory-confirmed cases of influenza H1N1 2009 in a subset of patients. FINDINGS: Pandemic H1N1 2009 influenza vaccination began in week 43 of 2009 (Oct 21, 2009) and was given to 38,296 (15·5%, 95% CI 15·4-15·6) of 247,178 people by the end of the study period (Jan 31, 2010). 208,882 (85%) people were unvaccinated. There were 5207 emergency hospital admissions and 579 deaths in the unvaccinated population and 924 hospital admissions and 71 deaths in the vaccinated population during 23,893,359 person-days of observation. The effectiveness of H1N1 vaccination for prevention of emergency hospital admissions from influenza-related disorders was 19·5% (95% CI 0·8-34·7). The vaccine's effectiveness in preventing laboratory-confirmed influenza was 77·0% (95% CI 2·0-95·0). INTERPRETATION: Pandemic H1N1 2009 influenza vaccination was associated with protection against pandemic influenza and a reduction in hospital admissions from influenza-related disorders in Scotland during the 2009-10 pandemic. FUNDING: National Institute for Health Research Health Technology Assessment Programme (UK).
BACKGROUND: A targeted vaccination programme for pandemic H1N1 2009 influenza was introduced in Scotland, UK, in October, 2009. We sought to assess the effectiveness of this vaccine in a sample of the Scottish population during the 2009-10 pandemic. METHODS: We assessed the effectiveness of the Scottish pandemic H1N1 2009 influenza vaccination with a retrospective cohort design. We linked data of patient-level primary care, hospital records, death certification, and virological swabs to construct our cohort. We estimated vaccine effectiveness in a nationally representative sample of the Scottish population by establishing the risk of hospital admission and death (adjusted for potential confounders) resulting from influenza-related morbidity in vaccinated and unvaccinated patients and laboratory-confirmed cases of influenza H1N1 2009 in a subset of patients. FINDINGS: Pandemic H1N1 2009 influenza vaccination began in week 43 of 2009 (Oct 21, 2009) and was given to 38,296 (15·5%, 95% CI 15·4-15·6) of 247,178 people by the end of the study period (Jan 31, 2010). 208,882 (85%) people were unvaccinated. There were 5207 emergency hospital admissions and 579 deaths in the unvaccinated population and 924 hospital admissions and 71 deaths in the vaccinated population during 23,893,359 person-days of observation. The effectiveness of H1N1 vaccination for prevention of emergency hospital admissions from influenza-related disorders was 19·5% (95% CI 0·8-34·7). The vaccine's effectiveness in preventing laboratory-confirmed influenza was 77·0% (95% CI 2·0-95·0). INTERPRETATION: Pandemic H1N1 2009 influenza vaccination was associated with protection against pandemic influenza and a reduction in hospital admissions from influenza-related disorders in Scotland during the 2009-10 pandemic. FUNDING: National Institute for Health Research Health Technology Assessment Programme (UK).
Authors: Ricardo Basurto-Dávila; Martin I Meltzer; Dora A Mills; Garrett R Beeler Asay; Bo-Hyun Cho; Samuel B Graitcer; Nancy L Dube; Mark G Thompson; Suchita A Patel; Samuel K Peasah; Jill M Ferdinands; Paul Gargiullo; Mark Messonnier; David K Shay Journal: Health Serv Res Date: 2017-12 Impact factor: 3.402
Authors: Colin R Simpson; Nazir I Lone; Kim Kavanagh; Tanya Englishby; Chris Robertson; Jim McMenamin; Beatrix von Wissman; Eleftheria Vasileiou; Christopher C Butler; Lewis D Ritchie; Rory Gunson; Jürgen Schwarze; Aziz Sheikh Journal: Health Technol Assess Date: 2020-12 Impact factor: 4.014
Authors: Colin R Simpson; Markus Fc Steiner; Genevieve Cezard; Narinder Bansal; Colin Fischbacher; Anne Douglas; Raj Bhopal; Aziz Sheikh Journal: J R Soc Med Date: 2015-07-07 Impact factor: 5.344