Literature DB >> 22738633

'Click' synthesis of a triazole-based inhibitor of Met functions in cancer cells.

Francesco Colombo1, Cristina Tintori, Alessandro Furlan, Stella Borrelli, Michael S Christodoulou, Rosanna Dono, Flavio Maina, Maurizio Botta, Mercedes Amat, Joan Bosch, Daniele Passarella.   

Abstract

The use of Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition permitted the synthesis of a new compound that is able to inhibit the HGF-induced scattering of MDCK (epithelial cells) and in vitro tumorigenesis of H1437 (non-small-cell lung cancer) and GTL-16 (human gastric carcinoma). In agreement with biochemical and biological results, docking studies within the ATP binding site of Met suggested for the new synthesized compound a binding mode similar to that of the active compound Triflorcas previously reported.
Copyright © 2012 Elsevier Ltd. All rights reserved.

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Year:  2012        PMID： 22738633     DOI： 10.1016/j.bmcl.2012.05.078

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  7 in total

1.  Aminopyridyl/Pyrazinyl Spiro[indoline-3,4'-piperidine]-2-ones As Highly Selective and Efficacious c-Met/ALK Inhibitors.

Authors:  Jingrong Li; Nan Wu; Yuanxin Tian; Jiajie Zhang; Shuguang Wu
Journal:  ACS Med Chem Lett       Date:  2013-07-12       Impact factor: 4.345

Review 2.  Amide Bond Bioisosteres: Strategies, Synthesis, and Successes.

Authors:  Shikha Kumari; Angelica V Carmona; Amit K Tiwari; Paul C Trippier
Journal:  J Med Chem       Date:  2020-08-04       Impact factor: 7.446

3.  Design and synthesis of isosteviol triazole conjugates for cancer therapy.

Authors:  Ravil N Khaybullin; Mei Zhang; Junjie Fu; Xiao Liang; Tammy Li; Alan R Katritzky; Paul Okunieff; Xin Qi
Journal:  Molecules       Date:  2014-11-14       Impact factor: 4.411

4.  Design and Synthesis of Hsp90 Inhibitors with B-Raf and PDHK1 Multi-Target Activity.

Authors:  Luca Pinzi; Francesca Foschi; Michael S Christodoulou; Daniele Passarella; Giulio Rastelli
Journal:  ChemistryOpen       Date:  2021-10-11       Impact factor: 2.630

Review 5.  CuAAC-ensembled 1,2,3-triazole-linked isosteres as pharmacophores in drug discovery: review.

Authors:  Alisha Rani; Gurjaspreet Singh; Akshpreet Singh; Ubair Maqbool; Gurpreet Kaur; Jandeep Singh
Journal:  RSC Adv       Date:  2020-02-04       Impact factor: 4.036

Review 6.  1,2,3-Triazoles as Biomimetics in Peptide Science.

Authors:  Naima Agouram; El Mestafa El Hadrami; Abdeslem Bentama
Journal:  Molecules       Date:  2021-05-14       Impact factor: 4.411

7.  Combined drug action of 2-phenylimidazo[2,1-b]benzothiazole derivatives on cancer cells according to their oncogenic molecular signatures.

Authors:  Alessandro Furlan; Benjamin Roux; Fabienne Lamballe; Filippo Conti; Nathalie Issaly; Fabrice Daian; Jean-François Guillemot; Sylvie Richelme; Magali Contensin; Joan Bosch; Daniele Passarella; Oreste Piccolo; Rosanna Dono; Flavio Maina
Journal:  PLoS One       Date:  2012-10-05       Impact factor: 3.240
  7 in total

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