Literature DB >> 22738198

A novel role for the transcription factor HIF-1α in the formation of mast cell extracellular traps.

Katja Branitzki-Heinemann1, Cheryl Y Okumura, Lena Völlger, Yuko Kawakami, Toshiaki Kawakami, Hassan Y Naim, Victor Nizet, Maren Von Köckritz-Blickwede.   

Abstract

MCs (mast cells) are critical components of the host innate immune defence against bacterial pathogens, providing a variety of intra- and extra-cellular antimicrobial functions. In the present study we show, for the first time, that the transcriptional regulator HIF-1α (hypoxia-inducible factor-1α) mediates the extracellular antimicrobial activity of human and murine MCs by increasing the formation of MCETs (MC extracellular traps).

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Year:  2012        PMID： 22738198      PMCID： PMC3606900          DOI： 10.1042/BJ20120658

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  16 in total

1.  Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity.

Authors:  Dehe Kong; Eun Jung Park; Andrew G Stephen; Maura Calvani; John H Cardellina; Anne Monks; Robert J Fisher; Robert H Shoemaker; Giovanni Melillo
Journal:  Cancer Res       Date:  2005-10-01       Impact factor: 12.701

2.  A new pharmacological agent (AKB-4924) stabilizes hypoxia inducible factor-1 (HIF-1) and increases skin innate defenses against bacterial infection.

Authors:  Cheryl Y M Okumura; Andrew Hollands; Dan N Tran; Joshua Olson; Samira Dahesh; Maren von Köckritz-Blickwede; Wdee Thienphrapa; Courtney Corle; Seung Nam Jeung; Anna Kotsakis; Robert A Shalwitz; Randall S Johnson; Victor Nizet
Journal:  J Mol Med (Berl)       Date:  2012-02-28       Impact factor: 4.599

3.  HIF-1alpha expression regulates the bactericidal capacity of phagocytes.

Authors:  Carole Peyssonnaux; Vivekanand Datta; Thorsten Cramer; Andrew Doedens; Emmanuel A Theodorakis; Richard L Gallo; Nancy Hurtado-Ziola; Victor Nizet; Randall S Johnson
Journal:  J Clin Invest       Date:  2005-07       Impact factor: 14.808

4.  Establishment of an immature mast cell line from a patient with mast cell leukemia.

Authors:  J H Butterfield; D Weiler; G Dewald; G J Gleich
Journal:  Leuk Res       Date:  1988       Impact factor: 3.156

5.  Mast cell phagocytosis of FimH-expressing enterobacteria.

Authors:  R Malaviya; E A Ross; J I MacGregor; T Ikeda; J R Little; B A Jakschik; S N Abraham
Journal:  J Immunol       Date:  1994-02-15       Impact factor: 5.422

6.  Cutting edge: mast cell antimicrobial activity is mediated by expression of cathelicidin antimicrobial peptide.

Authors:  Anna Di Nardo; Antonella Vitiello; Richard L Gallo
Journal:  J Immunol       Date:  2003-03-01       Impact factor: 5.422

Review 7.  Hypoxia inducible factor (HIF) function in innate immunity and infection.

Authors:  Annelies S Zinkernagel; Randall S Johnson; Victor Nizet
Journal:  J Mol Med (Berl)       Date:  2007-11-21       Impact factor: 4.599

8.  Dual effect of echinomycin on hypoxia-inducible factor-1 activity under normoxic and hypoxic conditions.

Authors:  Benoit Vlaminck; Sebastien Toffoli; Benjamin Ghislain; Catherine Demazy; Martine Raes; Carine Michiels
Journal:  FEBS J       Date:  2007-10-04       Impact factor: 5.542

9.  Pharmacologic augmentation of hypoxia-inducible factor-1alpha with mimosine boosts the bactericidal capacity of phagocytes.

Authors:  Annelies S Zinkernagel; Carole Peyssonnaux; Randall S Johnson; Victor Nizet
Journal:  J Infect Dis       Date:  2008-01-15       Impact factor: 5.226

10.  Expression of proinflammatory cytokines via HIF-1alpha and NF-kappaB activation on desferrioxamine-stimulated HMC-1 cells.

Authors:  Hyun-Ja Jeong; Hwan-Suck Chung; Bo-Ra Lee; Su-Jin Kim; Su-Jin Yoo; Seung-Heon Hong; Hyung-Min Kim
Journal:  Biochem Biophys Res Commun       Date:  2003-07-11       Impact factor: 3.575
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  16 in total

Review 1.  Oxygen sensing in intestinal mucosal inflammation.

Authors:  Katharina Flück; Joachim Fandrey
Journal:  Pflugers Arch       Date:  2015-07-25       Impact factor: 3.657

2.  Interferon-γ enhances both the anti-bacterial and the pro-inflammatory response of human mast cells to Staphylococcus aureus.

Authors:  Emily J Swindle; Jared M Brown; Madeleine Rådinger; Frank R DeLeo; Dean D Metcalfe
Journal:  Immunology       Date:  2015-10-05       Impact factor: 7.397

Review 3.  Hypoxia-Inducible Factor (HIF) as a Pharmacological Target for Prevention and Treatment of Infectious Diseases.

Authors:  Tamara Bhandari; Victor Nizet
Journal:  Infect Dis Ther       Date:  2014-06-24

Review 4.  Antimicrobial Activity of Mast Cells: Role and Relevance of Extracellular DNA Traps.

Authors:  Helene Möllerherm; Maren von Köckritz-Blickwede; Katja Branitzki-Heinemann
Journal:  Front Immunol       Date:  2016-07-18       Impact factor: 7.561

5.  Formation of Neutrophil Extracellular Traps under Low Oxygen Level.

Authors:  Katja Branitzki-Heinemann; Helene Möllerherm; Lena Völlger; Diab M Husein; Nicole de Buhr; Stefanie Blodkamp; Friederike Reuner; Graham Brogden; Hassan Y Naim; Maren von Köckritz-Blickwede
Journal:  Front Immunol       Date:  2016-11-25       Impact factor: 7.561

6.  Hypoxia Modulates the Response of Mast Cells to Staphylococcus aureus Infection.

Authors:  Helene Möllerherm; Katja Branitzki-Heinemann; Graham Brogden; Ayssar A Elamin; Wulf Oehlmann; Herbert Fuhrmann; Mahavir Singh; Hassan Y Naim; Maren von Köckritz-Blickwede
Journal:  Front Immunol       Date:  2017-05-11       Impact factor: 7.561

7.  Mast Cell Activation Protects Cornea by Promoting Neutrophil Infiltration via Stimulating ICAM-1 and Vascular Dilation in Fungal Keratitis.

Authors:  Yanting Xie; Hongmin Zhang; Susu Liu; Guoming Chen; Siyu He; Zhijie Li; Liya Wang
Journal:  Sci Rep       Date:  2018-05-30       Impact factor: 4.379

Review 8.  Intestinal Mucosal Mast Cells: Key Modulators of Barrier Function and Homeostasis.

Authors:  Mercé Albert-Bayo; Irene Paracuellos; Ana M González-Castro; Amanda Rodríguez-Urrutia; María J Rodríguez-Lagunas; Carmen Alonso-Cotoner; Javier Santos; María Vicario
Journal:  Cells       Date:  2019-02-08       Impact factor: 6.600

9.  The expanding world of extracellular traps: not only neutrophils but much more.

Authors:  Oliver Goldmann; Eva Medina
Journal:  Front Immunol       Date:  2013-01-11       Impact factor: 7.561

10.  Iron-chelating agent desferrioxamine stimulates formation of neutrophil extracellular traps (NETs) in human blood-derived neutrophils.

Authors:  Lena Völlger; Kathryn Akong-Moore; Linda Cox; Oliver Goldmann; Yanming Wang; Simon T Schäfer; Hassan Y Naim; Victor Nizet; Maren von Köckritz-Blickwede
Journal:  Biosci Rep       Date:  2016-05-20       Impact factor: 3.840
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