Literature DB >> 22737184

Identification of Enzyme Inhibitors Using Therapeutic Target Protein - Magnetic Nanoparticle Conjugates.

Lin-Sen Qing1, Nan Tang, Ying Xue, Jian Liang, Yi-Ming Liu, Xun Liao.   

Abstract

Target protein - magnetic nanoparticle (MNP) conjugates, i.e. α-glucosidase-MNP and protein tyrosine phosphatase 1B (PTP1B)-MNP, were prepared and evaluated for the first time for affinity extraction of the enzyme inhibitors from herbal extracts. Four ligands extracted from granati pericarpium were identified by ESI-MS analysis. In vitro tests indicated that they inhibited both α-glucosidase and PTP1B, two important target proteins for diabetic treatment.

Entities:  

Year:  2012        PMID： 22737184      PMCID： PMC3378064          DOI： 10.1039/C2AY25320H

Source DB:  PubMed          Journal:  Anal Methods        ISSN： 1759-9660            Impact factor:   2.896


  33 in total

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