Literature DB >> 2273651

Effect of omeprazole on delayed healing of acetic acid-induced gastric ulcers in rats.

J Y Wang1, H Nagai, S Okabe.   

Abstract

Omeprazole, a gastric mucosal proton pump inhibitor, significantly and dose-dependently prevented the delayed healing of acetic acid-induced gastric ulcers in response to repeatedly administered indomethacin to rats. Both basal and histamine-stimulated gastric acid secretions in rats with acetic acid-induced ulcers that were given indomethacin were markedly and persistently (greater than 24 hr) inhibited after 4 weeks treatment with omeprazole. The prevention of delayed ulcer healing by omeprazole appears to be due to its long-lasting antisecretory activity.

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Year:  1990        PMID： 2273651     DOI： 10.1254/jjp.54.82

Source DB:  PubMed          Journal:  Jpn J Pharmacol        ISSN： 0021-5198


  6 in total

1.  Fibroblast growth factor in gastroprotection and ulcer healing: interaction with sucralfate.

Authors:  S J Konturek; T Brzozowski; J Majka; A Szlachcic; W Bielanski; J Stachura; W Otto
Journal:  Gut       Date:  1993-07       Impact factor: 23.059

2.  Cytoprotection and healing: two unequal brethren.

Authors:  F Halter; B Peskar; K D Rainsford; A Schmassmann
Journal:  Inflammopharmacology       Date:  1997       Impact factor: 4.473

3.  Effects of nonsteroidal antiinflammatory drugs on ulcerogenesis and gastric secretion in pylorus-ligated rat.

Authors:  K A Wagner; J Nandi; R L King; R A Levine
Journal:  Dig Dis Sci       Date:  1995-01       Impact factor: 3.199

4.  Healing and Antisecretory Effects of Aqueous Extract of Eremomastax speciosa (Acanthaceae) on Unhealed Gastric Ulcers.

Authors:  A P Amang; C Mezui; G T Siwe; J Emakoua; G Mbah; E Z Nkwengoua; G E Enow-Orock; P V Tan
Journal:  Biomed Res Int       Date:  2017-10-19       Impact factor: 3.411

5.  Impairment of gastric ulcer healing by alendronate, a nitrogen-containing bisphosphonate, in rats.

Authors:  Kikuko Amagase; Shusaku Hayashi; Kaoru Nishikawa; Eitaro Aihara; Koji Takeuchi
Journal:  Dig Dis Sci       Date:  2007-04-05       Impact factor: 3.487

6.  Royal jelly accelerates healing of acetate induced gastric ulcers in male rats.

Authors:  Mohammad Sofiabadi; Fatemeh Samiee-Rad
Journal:  Gastroenterol Hepatol Bed Bench       Date:  2020
  6 in total

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