| Literature DB >> 22735574 |
C C Correa1, W C Aw, R G Melvin, N Pichaud, J W O Ballard.
Abstract
The influence of mitochondrial DNA (mtDNA) mutations on human disease has been extensively studied, but the impact of mutations within the adaptive range is debated. We studied males from lines of Drosophila melanogaster that have a highly standardized nuclear genome but different mtDNA, at two ages. We measured mitochondrial respiration on permeabilized muscle fibers, hydrogen peroxide production of isolated mitochondria and mtDNA copy number of whole individuals. The results show that a small set of naturally occurring mtDNA mutations can have a significant influence on mitochondrial bioenergetics that may change as the organism ages.Entities:
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Year: 2012 PMID： 22735574 DOI： 10.1016/j.mito.2012.06.005
Source DB: PubMed Journal: Mitochondrion ISSN： 1567-7249 Impact factor: 4.160