INTRODUCTION: Cognitive impairment is common in Parkinson's disease (PD), even in the early stages, and appropriate screening tools are needed. METHODS: We investigated the utility of the Addenbrooke's Cognitive Examination-Revised for detecting mild cognitive impairment (MCI) in PD in an incident population-representative cohort (n = 132) and investigated the relationship between performance on this instrument and behavior and quality of life (n = 219). RESULTS: Twenty-two percent met criteria for MCI. Receiver operating curve analysis revealed an area under the curve of 0.81. A cutoff <89 gave a sensitivity of 69% and specificity of 84%. Scores on this instrument were highly correlated with the Parkinson's Disease Cognitive Rating Scale, and there were significant correlations with the Cambridge Behavioral Inventory-Revised and Parkinson's Disease Questionnaire 39. CONCLUSION: This instrument is a useful screening tool for PD-MCI, and poor performance is significantly related to impaired behavior and quality of life.
INTRODUCTION: Cognitive impairment is common in Parkinson's disease (PD), even in the early stages, and appropriate screening tools are needed. METHODS: We investigated the utility of the Addenbrooke's Cognitive Examination-Revised for detecting mild cognitive impairment (MCI) in PD in an incident population-representative cohort (n = 132) and investigated the relationship between performance on this instrument and behavior and quality of life (n = 219). RESULTS: Twenty-two percent met criteria for MCI. Receiver operating curve analysis revealed an area under the curve of 0.81. A cutoff <89 gave a sensitivity of 69% and specificity of 84%. Scores on this instrument were highly correlated with the Parkinson's Disease Cognitive Rating Scale, and there were significant correlations with the Cambridge Behavioral Inventory-Revised and Parkinson's Disease Questionnaire 39. CONCLUSION: This instrument is a useful screening tool for PD-MCI, and poor performance is significantly related to impaired behavior and quality of life.
Authors: Rachel H Tan; Emma Devenney; Carol Dobson-Stone; John B Kwok; John R Hodges; Matthew C Kiernan; Glenda M Halliday; Michael Hornberger Journal: PLoS One Date: 2014-08-21 Impact factor: 3.240
Authors: Liam McAuliffe; Gaynor C Parfitt; Roger G Eston; Caitlin Gray; Hannah A D Keage; Ashleigh E Smith Journal: BMC Sports Sci Med Rehabil Date: 2018-01-30
Authors: Timothy Rittman; Boyd C Ghosh; Peter McColgan; David P Breen; Jonathan Evans; Caroline H Williams-Gray; Roger A Barker; James B Rowe Journal: J Neurol Neurosurg Psychiatry Date: 2013-01-08 Impact factor: 10.154