BACKGROUND: Obesity is associated with lowgrade systemic inflammation which has been linked to the increased risk of cardiovascular disease and Type 2 diabetes in obese patients. AIM: To evaluate changes in pro/anti-inflammatory adipocytokines and metabolic profile after moderate diet-induced weight loss. SUBJECTS AND METHODS: Twenty-nine pre-menopausal obese women (body mass index ≥30 kg/m2) aged 21 to 54 years without diabetes, hypertension, or hyperlipidemia, were enrolled in this study. We measured anthropometric parameters, lipid and glucose profiles, interleukin (IL)-6, IL-10, and IL-18 in obese women, who then entered a medically supervised program aimed at reducing body weight by 10% or more. Obese women restricted their caloric intake (by 500-1000 kcal/day) and consumed 50 g/day of a fiber supplement (Slim Last Powder) for 12 weeks. RESULTS: By completing the dietary intervention program, weight (Δ = -10.0%, p<0.0001), body mass index, waist circumference, triceps skinfold thickness, total cholesterol, triglyceride, and fasting plasma glucose significantly decreased, while HDL-cholesterol significantly increased. While plasma levels of IL-6 and IL-18 decreased by 27% after 12 weeks, no significant change was observed in circulating levels of IL-10. CONCLUSION: Our study suggests that an improved body composition induced by restriction of energy intake is associated with favorable serum concentrations of IL-6 and IL-18 in obese women. However, the anti-inflammatory IL-10 is not affected by a moderate weight decrease.
BACKGROUND: Obesity is associated with lowgrade systemic inflammation which has been linked to the increased risk of cardiovascular disease and Type 2 diabetes in obesepatients. AIM: To evaluate changes in pro/anti-inflammatory adipocytokines and metabolic profile after moderate diet-induced weight loss. SUBJECTS AND METHODS: Twenty-nine pre-menopausal obesewomen (body mass index ≥30 kg/m2) aged 21 to 54 years without diabetes, hypertension, or hyperlipidemia, were enrolled in this study. We measured anthropometric parameters, lipid and glucose profiles, interleukin (IL)-6, IL-10, and IL-18 in obesewomen, who then entered a medically supervised program aimed at reducing body weight by 10% or more. Obesewomen restricted their caloric intake (by 500-1000 kcal/day) and consumed 50 g/day of a fiber supplement (Slim Last Powder) for 12 weeks. RESULTS: By completing the dietary intervention program, weight (Δ = -10.0%, p<0.0001), body mass index, waist circumference, triceps skinfold thickness, total cholesterol, triglyceride, and fasting plasma glucose significantly decreased, while HDL-cholesterol significantly increased. While plasma levels of IL-6 and IL-18 decreased by 27% after 12 weeks, no significant change was observed in circulating levels of IL-10. CONCLUSION: Our study suggests that an improved body composition induced by restriction of energy intake is associated with favorable serum concentrations of IL-6 and IL-18 in obesewomen. However, the anti-inflammatory IL-10 is not affected by a moderate weight decrease.
Authors: Johannes Hulthe; William McPheat; Ann Samnegård; Per Tornvall; Anders Hamsten; Per Eriksson Journal: Atherosclerosis Date: 2006-01-06 Impact factor: 5.162
Authors: V Mohamed-Ali; S Goodrick; A Rawesh; D R Katz; J M Miles; J S Yudkin; S Klein; S W Coppack Journal: J Clin Endocrinol Metab Date: 1997-12 Impact factor: 5.958
Authors: M R Manigrasso; P Ferroni; F Santilli; T Taraborelli; M T Guagnano; N Michetti; G Davì Journal: J Clin Endocrinol Metab Date: 2005-07-19 Impact factor: 5.958
Authors: Joan Vendrell; Montserrat Broch; Nuria Vilarrasa; Ana Molina; Jose Manuel Gómez; Cristina Gutiérrez; Immaculada Simón; Joan Soler; Cristóbal Richart Journal: Obes Res Date: 2004-06
Authors: N Yamada; H Yoshinaga; N Sakurai; H Shimano; T Gotoda; Y Ohashi; Y Yazaki; K Kosaka Journal: Diabetes Care Date: 1994-02 Impact factor: 19.112
Authors: Stefan Jordan; Navpreet Tung; Maria Casanova-Acebes; Christie Chang; Claudia Cantoni; Dachuan Zhang; Theresa H Wirtz; Shruti Naik; Samuel A Rose; Chad N Brocker; Anastasiia Gainullina; Daniel Hornburg; Sam Horng; Barbara B Maier; Paolo Cravedi; Derek LeRoith; Frank J Gonzalez; Felix Meissner; Jordi Ochando; Adeeb Rahman; Jerry E Chipuk; Maxim N Artyomov; Paul S Frenette; Laura Piccio; Marie-Luise Berres; Emily J Gallagher; Miriam Merad Journal: Cell Date: 2019-08-22 Impact factor: 41.582