Literature DB >> 22733072

Novel mechanism for fluoroquinolone resistance in Acinetobacter baumannii.

Sunil D Saroj1, Katy M Clemmer, Robert A Bonomo, Philip N Rather.   

Abstract

An EZ::TN<R6Kγori/KAN-2>Tnp transposon insertion in an open reading frame of unknown function (ncr) in Acinetobacter baumannii resulted in an 8-fold increase in ciprofloxacin resistance (Cip(r)). Transposon insertions in an ncr mutant that reduced Cip(r) back to wild type mapped to three genes encoding subunits of the RecCBD exonuclease. The ncr mutation increased transcription of the recCBD genes, and overexpression of the recCBD genes in a wild-type background resulted in a 4-fold increase in Cip(r).

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Year:  2012        PMID： 22733072      PMCID： PMC3421888          DOI： 10.1128/AAC.00739-12

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  19 in total

Review 1.  The threat from the pink corner.

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Journal:  Ann Med       Date:  2003       Impact factor: 4.709

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Journal:  Infect Control Hosp Epidemiol       Date:  2010-07       Impact factor: 3.254

Review 3.  Global challenge of multidrug-resistant Acinetobacter baumannii.

Authors:  Federico Perez; Andrea M Hujer; Kristine M Hujer; Brooke K Decker; Philip N Rather; Robert A Bonomo
Journal:  Antimicrob Agents Chemother       Date:  2007-07-23       Impact factor: 5.191

Review 4.  RecBCD enzyme and the repair of double-stranded DNA breaks.

Authors:  Mark S Dillingham; Stephen C Kowalczykowski
Journal:  Microbiol Mol Biol Rev       Date:  2008-12       Impact factor: 11.056

5.  Construction of broad-host-range plasmid vectors for easy visible selection and analysis of promoters.

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Journal:  J Bacteriol       Date:  1990-06       Impact factor: 3.490

6.  Antibiotic-mediated recombination: ciprofloxacin stimulates SOS-independent recombination of divergent sequences in Escherichia coli.

Authors:  Elena López; Marina Elez; Ivan Matic; Jesús Blázquez
Journal:  Mol Microbiol       Date:  2007-04       Impact factor: 3.501

7.  Analysis and nucleotide sequence of an origin of DNA replication in Acinetobacter calcoaceticus and its use for Escherichia coli shuttle plasmids.

Authors:  M Hunger; R Schmucker; V Kishan; W Hillen
Journal:  Gene       Date:  1990-03-01       Impact factor: 3.688

Review 8.  Acinetobacter baumannii: an emerging multidrug-resistant threat.

Authors:  Thomas D Gootz; Andrea Marra
Journal:  Expert Rev Anti Infect Ther       Date:  2008-06       Impact factor: 5.091

Review 9.  Acinetobacter baumannii: emergence of a successful pathogen.

Authors:  Anton Y Peleg; Harald Seifert; David L Paterson
Journal:  Clin Microbiol Rev       Date:  2008-07       Impact factor: 26.132

10.  A wide-host-range suicide vector for improving reverse genetics in gram-negative bacteria: inactivation of the blaA gene of Yersinia enterocolitica.

Authors:  K Kaniga; I Delor; G R Cornelis
Journal:  Gene       Date:  1991-12-20       Impact factor: 3.688
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  9 in total

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Journal:  J Antibiot (Tokyo)       Date:  2014-11-05       Impact factor: 2.649

2.  Immunosuppression broadens evolutionary pathways to drug resistance and treatment failure during Acinetobacter baumannii pneumonia in mice.

Authors:  Wenwen Huo; Lindsay M Busch; Juan Hernandez-Bird; Efrat Hamami; Christopher W Marshall; Edward Geisinger; Vaughn S Cooper; Tim van Opijnen; Jason W Rosch; Ralph R Isberg
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3.  A genome-wide atlas of antibiotic susceptibility targets and pathways to tolerance.

Authors:  Dmitry Leshchiner; Federico Rosconi; Bharathi Sundaresh; Emily Rudmann; Luisa Maria Nieto Ramirez; Andrew T Nishimoto; Stephen J Wood; Bimal Jana; Noemí Buján; Kaicheng Li; Jianmin Gao; Matthew Frank; Stephanie M Reeve; Richard E Lee; Charles O Rock; Jason W Rosch; Tim van Opijnen
Journal:  Nat Commun       Date:  2022-06-07       Impact factor: 17.694

4.  Streptomycin inhibits quorum sensing in Acinetobacter baumannii.

Authors:  Sunil D Saroj; Philip N Rather
Journal:  Antimicrob Agents Chemother       Date:  2013-01-14       Impact factor: 5.191

5.  Draft Genome Sequence of the Clinical Isolate Acinetobacter nosocomialis Strain M2.

Authors:  Michael D Carruthers; Christian M Harding; Beth D Baker; Robert A Bonomo; Kristine M Hujer; Philip N Rather; Robert S Munson
Journal:  Genome Announc       Date:  2013-11-07

6.  Sulbactam enhances the in vitro activity of sitafloxacin against extensively-drug resistant Acinetobacter baumannii.

Authors:  Nannan Xu; Gang Wang; Yan Leng; Xiaomeng Dong; Fengzhe Chen; Quantai Xing
Journal:  Exp Ther Med       Date:  2018-08-20       Impact factor: 2.447

7.  The Landscape of Phenotypic and Transcriptional Responses to Ciprofloxacin in Acinetobacter baumannii: Acquired Resistance Alleles Modulate Drug-Induced SOS Response and Prophage Replication.

Authors:  Edward Geisinger; Germán Vargas-Cuebas; Nadav J Mortman; Sapna Syal; Yunfei Dai; Elizabeth L Wainwright; David Lazinski; Stephen Wood; Zeyu Zhu; Jon Anthony; Tim van Opijnen; Ralph R Isberg
Journal:  mBio       Date:  2019-06-11       Impact factor: 7.867

8.  The waaL gene mutation compromised the inhabitation of Enterobacter sp. Ag1 in the mosquito gut environment.

Authors:  Dong Pei; Jinjin Jiang; Wanqin Yu; Phanidhar Kukutla; Alejandro Uentillie; Jiannong Xu
Journal:  Parasit Vectors       Date:  2015-08-27       Impact factor: 3.876

9.  Resistance to pentamidine is mediated by AdeAB, regulated by AdeRS, and influenced by growth conditions in Acinetobacter baumannii ATCC 17978.

Authors:  Felise G Adams; Uwe H Stroeher; Karl A Hassan; Shashikanth Marri; Melissa H Brown
Journal:  PLoS One       Date:  2018-05-11       Impact factor: 3.240
  9 in total

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