Literature DB >> 2273299

Phase II evaluation of recombinant interferon-beta (IFN-beta ser) in patients with diffuse mesothelioma: a Southwest Oncology Group study.

D D Von Hoff1, B Metch, J G Lucas, S P Balcerzak, S M Grunberg, S E Rivkin.   

Abstract

Fourteen evaluable patients with diffuse malignant mesothelioma were treated with a once-a-day for 5 days out of 7 for 6 weeks regimen of recombinant interferon-beta (IFN-beta ser). No responses were noted. The major toxicities included fever, chills, nausea, vomiting, and anorexia. IFN-beta ser at this dose and schedule does not appear to be an active single agent for patients with refractory malignant mesothelioma.

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Year:  1990        PMID: 2273299     DOI: 10.1089/jir.1990.10.531

Source DB:  PubMed          Journal:  J Interferon Res        ISSN: 0197-8357


  5 in total

1.  A phase II trial investigating primary immunochemotherapy for malignant pleural mesothelioma and the feasibility of adjuvant immunochemotherapy after maximal cytoreduction.

Authors:  H W Pass; B K Temeck; K Kranda; S M Steinberg; H I Pass
Journal:  Ann Surg Oncol       Date:  1995-05       Impact factor: 5.344

Review 2.  Malignant mesothelioma: new insights into tumour biology and immunology as a basis for new treatment approaches.

Authors:  J W Upham; M J Garlepp; A W Musk; B W Robinson
Journal:  Thorax       Date:  1995-08       Impact factor: 9.139

3.  Treatment of a patient with malignant mesothelioma with interferon-alpha 2 based on in vitro sensitivity tests.

Authors:  V Sexl; L Wagner; M Wiesholzer; E Presterl; W Base
Journal:  Clin Investig       Date:  1994-03

4.  High-dose methotrexate in combination with interferons in the treatment of malignant pleural mesothelioma.

Authors:  M Halme; A Knuuttila; T Vehmas; L Tammilehto; M Mäntylä; J Salo; K Mattson
Journal:  Br J Cancer       Date:  1999-08       Impact factor: 7.640

5.  Intrapleural Adenoviral-mediated Endothelial Cell Protein C Receptor Gene Transfer Suppresses the Progression of Malignant Pleural Mesothelioma in a Mouse Model.

Authors:  Shiva Keshava; L Vijaya Mohan Rao; Usha R Pendurthi
Journal:  Sci Rep       Date:  2016-11-11       Impact factor: 4.379

  5 in total

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