Hiroshi Imamura1, Jiro Hata, Ai Iida, Noriaki Manabe, Ken Haruma. 1. Division of Endoscopy and Ultrasound, Department of Clinical Pathology and Laboratory Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama 701-0192, Japan. Imamura@med.kawasaki-m.ac.jp
Abstract
PURPOSE:Contrast-enhanced ultrasonography (CEUS) is a novel approach used for measuring organ perfusion changes. Studies using CEUS to assess the effects of non-steroidal anti-inflammatory drugs (NSAIDs) on renal blood flow (RBF) have not yet been conducted. We aimed to evaluate the effects of NSAIDs on the renal hemodynamics of healthy subjects with CEUS. METHODS: We performed CEUS using the bolus injection method in a total of 10 healthy subjects. Measurements were completed over two study days in a randomized, crossover manner. On each study day, CEUS was performed twice, before and after the administration of NSAIDs. Subjects received an injection of contrast medium and images were recorded. A region-of-interest (ROI) was selected within the renal cortex, signal intensity in the ROI of the kidney was measured and a time-intensity curve (TIC) was automatically generated with attached software. RESULTS: The mean (±SD) peak intensity decreased significantly after an administration of diclofenac sodium (from 26.0 × 10(-4) ± 17.4× 10(-4) AU to 19.2 × 10(-4) ± 12.0 × 10(-4) AU; P = 0.022), but not significantly with etodolac (from 26.5 × 10(-4) ± 9.7 × 10(-4) AU to 25.9 × 10(-4) ± 20.8× 10(-4) AU; P = 0.474). The mean (±SD) percent reduction in intensity following diclofenac sodium administration was significantly reduced compared with etodolac administration (22.2 ± 20.5 % vs. 3.4 ± 8.9 %, P = 0.037). CONCLUSIONS: These finding suggests that diclofenac sodium (P = 0.022), but not etodolac (P = 0.474), affects renal hemodynamics even in healthy subjects.
RCT Entities:
PURPOSE: Contrast-enhanced ultrasonography (CEUS) is a novel approach used for measuring organ perfusion changes. Studies using CEUS to assess the effects of non-steroidal anti-inflammatory drugs (NSAIDs) on renal blood flow (RBF) have not yet been conducted. We aimed to evaluate the effects of NSAIDs on the renal hemodynamics of healthy subjects with CEUS. METHODS: We performed CEUS using the bolus injection method in a total of 10 healthy subjects. Measurements were completed over two study days in a randomized, crossover manner. On each study day, CEUS was performed twice, before and after the administration of NSAIDs. Subjects received an injection of contrast medium and images were recorded. A region-of-interest (ROI) was selected within the renal cortex, signal intensity in the ROI of the kidney was measured and a time-intensity curve (TIC) was automatically generated with attached software. RESULTS: The mean (±SD) peak intensity decreased significantly after an administration of diclofenac sodium (from 26.0 × 10(-4) ± 17.4 × 10(-4) AU to 19.2 × 10(-4) ± 12.0 × 10(-4) AU; P = 0.022), but not significantly with etodolac (from 26.5 × 10(-4) ± 9.7 × 10(-4) AU to 25.9 × 10(-4) ± 20.8 × 10(-4) AU; P = 0.474). The mean (±SD) percent reduction in intensity following diclofenac sodium administration was significantly reduced compared with etodolac administration (22.2 ± 20.5 % vs. 3.4 ± 8.9 %, P = 0.037). CONCLUSIONS: These finding suggests that diclofenac sodium (P = 0.022), but not etodolac (P = 0.474), affects renal hemodynamics even in healthy subjects.
Authors: Antoine G Schneider; Lucie Hofmann; Grégoire Wuerzner; Nicolas Glatz; Marc Maillard; Jean-Yves Meuwly; Philippe Eggimann; Michel Burnier; Bruno Vogt Journal: Nephrol Dial Transplant Date: 2011-06-20 Impact factor: 5.992
Authors: K Farker; U Merkel; H Schweer; J Haerting; S F Madani; R Eggers; U A Müller; H W Seyberth; A Hoffmann Journal: Eur J Clin Pharmacol Date: 2002-03-28 Impact factor: 2.953
Authors: Martin Ritt; Rolf Janka; Markus P Schneider; Petros Martirosian; Joachim Hornegger; Werner Bautz; Michael Uder; Roland E Schmieder Journal: Nephrol Dial Transplant Date: 2009-11-24 Impact factor: 5.992
Authors: Johanna Störmer; Wilfried Gwinner; Katja Derlin; Stephan Immenschuh; Song Rong; Mi-Sun Jang; Nelli Shushakova; Hermann Haller; Faikah Gueler; Robert Greite Journal: Biomedicines Date: 2022-05-22