Literature DB >> 22732550

Human atrial fibrillation: insights from computational electrophysiological models.

Donald M Bers1, Eleonora Grandi.   

Abstract

Computational electrophysiology has proven useful to investigate the mechanisms of cardiac arrhythmias at various spatial scales, from isolated myocytes to the whole heart. This article reviews how mathematical modeling has aided our understanding of human atrial myocyte electrophysiology to study the contribution of structural and electrical remodeling to human atrial fibrillation. Potential new avenues of investigation and model development are suggested.
Copyright © 2011 Elsevier Inc. All rights reserved.

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Year:  2011        PMID： 22732550      PMCID： PMC3384487          DOI： 10.1016/j.tcm.2012.04.004

Source DB:  PubMed          Journal:  Trends Cardiovasc Med        ISSN： 1050-1738            Impact factor:   6.677


  63 in total

1.  Ionic mechanisms underlying human atrial action potential properties: insights from a mathematical model.

Authors:  M Courtemanche; R J Ramirez; S Nattel
Journal:  Am J Physiol       Date:  1998-07

2.  Mathematical model of an adult human atrial cell: the role of K+ currents in repolarization.

Authors:  A Nygren; C Fiset; L Firek; J W Clark; D S Lindblad; R B Clark; W R Giles
Journal:  Circ Res       Date:  1998 Jan 9-23       Impact factor: 17.367

3.  Adrenergic modulation of ultrarapid delayed rectifier K+ current in human atrial myocytes.

Authors:  G R Li; J Feng; Z Wang; B Fermini; S Nattel
Journal:  Circ Res       Date:  1996-05       Impact factor: 17.367

4.  Ionic determinants of functional reentry in a 2-D model of human atrial cells during simulated chronic atrial fibrillation.

Authors:  Sandeep V Pandit; Omer Berenfeld; Justus M B Anumonwo; Roman M Zaritski; James Kneller; Stanley Nattel; José Jalife
Journal:  Biophys J       Date:  2005-03-25       Impact factor: 4.033

5.  The G protein-gated potassium current I(K,ACh) is constitutively active in patients with chronic atrial fibrillation.

Authors:  D Dobrev; A Friedrich; N Voigt; N Jost; E Wettwer; T Christ; M Knaut; U Ravens
Journal:  Circulation       Date:  2005-12-05       Impact factor: 29.690

6.  Outward K+ current densities and Kv1.5 expression are reduced in chronic human atrial fibrillation.

Authors:  D R Van Wagoner; A L Pond; P M McCarthy; J S Trimmer; J M Nerbonne
Journal:  Circ Res       Date:  1997-06       Impact factor: 17.367

7.  Atrial L-type Ca2+ currents and human atrial fibrillation.

Authors:  D R Van Wagoner; A L Pond; M Lamorgese; S S Rossie; P M McCarthy; J M Nerbonne
Journal:  Circ Res       Date:  1999-09-03       Impact factor: 17.367

8.  Role of up-regulation of IK1 in action potential shortening associated with atrial fibrillation in humans.

Authors:  Henggui Zhang; Clifford J Garratt; Jiujiang Zhu; Arun V Holden
Journal:  Cardiovasc Res       Date:  2005-02-24       Impact factor: 10.787

9.  Spectral analysis identifies sites of high-frequency activity maintaining atrial fibrillation in humans.

Authors:  Prashanthan Sanders; Omer Berenfeld; Mélèze Hocini; Pierre Jaïs; Ravi Vaidyanathan; Li-Fern Hsu; Stéphane Garrigue; Yoshihide Takahashi; Martin Rotter; Fréderic Sacher; Christophe Scavée; Robert Ploutz-Snyder; José Jalife; Michel Haïssaguerre
Journal:  Circulation       Date:  2005-08-01       Impact factor: 29.690

10.  Alterations in muscarinic K+ channel response to acetylcholine and to G protein-mediated activation in atrial myocytes isolated from failing human hearts.

Authors:  S Koumi; C E Arentzen; C L Backer; J A Wasserstrom
Journal:  Circulation       Date:  1994-11       Impact factor: 29.690
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  14 in total

Review 1.  Computational modeling: What does it tell us about atrial fibrillation therapy?

Authors:  Eleonora Grandi; Dobromir Dobrev; Jordi Heijman
Journal:  Int J Cardiol       Date:  2019-01-25       Impact factor: 4.164

Review 2.  Sodium-calcium exchangers (NCX): molecular hallmarks underlying the tissue-specific and systemic functions.

Authors:  Daniel Khananshvili
Journal:  Pflugers Arch       Date:  2013-11-27       Impact factor: 3.657

Review 3.  Mathematical approaches to understanding and imaging atrial fibrillation: significance for mechanisms and management.

Authors:  Natalia A Trayanova
Journal:  Circ Res       Date:  2014-04-25       Impact factor: 17.367

4.  Populations of in silico myocytes and tissues reveal synergy of multiatrial-predominant K+ -current block in atrial fibrillation.

Authors:  Haibo Ni; Alex Fogli Iseppe; Wayne R Giles; Sanjiv M Narayan; Henggui Zhang; Andrew G Edwards; Stefano Morotti; Eleonora Grandi
Journal:  Br J Pharmacol       Date:  2020-08-09       Impact factor: 8.739

Review 5.  Potassium currents in the heart: functional roles in repolarization, arrhythmia and therapeutics.

Authors:  Nipavan Chiamvimonvat; Ye Chen-Izu; Colleen E Clancy; Isabelle Deschenes; Dobromir Dobrev; Jordi Heijman; Leighton Izu; Zhilin Qu; Crystal M Ripplinger; Jamie I Vandenberg; James N Weiss; Gideon Koren; Tamas Banyasz; Eleonora Grandi; Michael C Sanguinetti; Donald M Bers; Jeanne M Nerbonne
Journal:  J Physiol       Date:  2017-01-05       Impact factor: 5.182

6.  Multi-scale Modeling of the Cardiovascular System: Disease Development, Progression, and Clinical Intervention.

Authors:  Yanhang Zhang; Victor H Barocas; Scott A Berceli; Colleen E Clancy; David M Eckmann; Marc Garbey; Ghassan S Kassab; Donna R Lochner; Andrew D McCulloch; Roger Tran-Son-Tay; Natalia A Trayanova
Journal:  Ann Biomed Eng       Date:  2016-05-02       Impact factor: 3.934

7.  Revealing kinetics and state-dependent binding properties of IKur-targeting drugs that maximize atrial fibrillation selectivity.

Authors:  Nicholas Ellinwood; Dobromir Dobrev; Stefano Morotti; Eleonora Grandi
Journal:  Chaos       Date:  2017-09       Impact factor: 3.642

Review 8.  Computational models of atrial cellular electrophysiology and calcium handling, and their role in atrial fibrillation.

Authors:  Jordi Heijman; Pegah Erfanian Abdoust; Niels Voigt; Stanley Nattel; Dobromir Dobrev
Journal:  J Physiol       Date:  2015-12-28       Impact factor: 5.182

Review 9.  Fibroblast-myocyte electrotonic coupling: does it occur in native cardiac tissue?

Authors:  Peter Kohl; Robert G Gourdie
Journal:  J Mol Cell Cardiol       Date:  2014-01-08       Impact factor: 5.000

Review 10.  Human atrial cell models to analyse haemodialysis-related effects on cardiac electrophysiology: work in progress.

Authors:  Elisa Passini; Simonetta Genovesi; Stefano Severi
Journal:  Comput Math Methods Med       Date:  2014-12-23       Impact factor: 2.238
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