Literature DB >> 22730246

Development and application of a fluoride-detection-based fluorescence assay for γ-butyrobetaine hydroxylase.

Anna M Rydzik1, Ivanhoe K H Leung, Grazyna T Kochan, Armin Thalhammer, Udo Oppermann, Timothy D W Claridge, Christopher J Schofield.   

Abstract

Fluoride assays for oxygenases: The 2-oxoglutarate-dependent oxygenase BBOX catalyses the final step in carnitine biosynthesis and is a medicinal chemistry target. We report that BBOX can hydroxylate fluorinated substrates analogues with subsequent release of a fluoride ion, thereby enabling an efficient fluorescence-based assay.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2012        PMID： 22730246     DOI： 10.1002/cbic.201200256

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


  12 in total

1.  Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases.

Authors:  Nathan R Rose; Esther C Y Woon; Anthony Tumber; Louise J Walport; Rasheduzzaman Chowdhury; Xuan Shirley Li; Oliver N F King; Clarisse Lejeune; Stanley S Ng; Tobias Krojer; Mun Chiang Chan; Anna M Rydzik; Richard J Hopkinson; Ka Hing Che; Michelle Daniel; Claire Strain-Damerell; Carina Gileadi; Grazyna Kochan; Ivanhoe K H Leung; James Dunford; Kar Kheng Yeoh; Peter J Ratcliffe; Nicola Burgess-Brown; Frank von Delft; Susanne Muller; Brian Marsden; Paul E Brennan; Michael A McDonough; Udo Oppermann; Robert J Klose; Christopher J Schofield; Akane Kawamura
Journal:  J Med Chem       Date:  2012-07-11       Impact factor: 7.446

2.  Modulating carnitine levels by targeting its biosynthesis pathway - selective inhibition of γ-butyrobetaine hydroxylase.

Authors:  Anna M Rydzik; Rasheduzzaman Chowdhury; Grazyna T Kochan; Sophie T Williams; Michael A McDonough; Akane Kawamura; Christopher J Schofield
Journal:  Chem Sci       Date:  2014-05-01       Impact factor: 9.825

Review 3.  Carbon-fluorine bond cleavage mediated by metalloenzymes.

Authors:  Yifan Wang; Aimin Liu
Journal:  Chem Soc Rev       Date:  2020-06-08       Impact factor: 54.564

4.  5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation.

Authors:  Richard J Hopkinson; Anthony Tumber; Clarence Yapp; Rasheduzzaman Chowdhury; WeiShen Aik; Ka Hing Che; Xuan Shirley Li; Jan B L Kristensen; Oliver N F King; Mun Chiang Chan; Kar Kheng Yeoh; Hwanho Choi; Louise J Walport; Cyrille C Thinnes; Jacob T Bush; Clarisse Lejeune; Anna M Rydzik; Nathan R Rose; Eleanor A Bagg; Michael A McDonough; Tobias Krojer; Wyatt W Yue; Stanley S Ng; Lars Olsen; Paul E Brennan; Udo Oppermann; Susanne Muller-Knapp; Robert J Klose; Peter J Ratcliffe; Christopher J Schofield; Akane Kawamura
Journal:  Chem Sci       Date:  2013-08-01       Impact factor: 9.825

5.  Human Oxygenase Variants Employing a Single Protein FeII Ligand Are Catalytically Active.

Authors:  Amelia Brasnett; Inga Pfeffer; Lennart Brewitz; Rasheduzzaman Chowdhury; Yu Nakashima; Anthony Tumber; Michael A McDonough; Christopher J Schofield
Journal:  Angew Chem Int Ed Engl       Date:  2021-05-19       Impact factor: 16.823

6.  Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain.

Authors:  Mun Chiang Chan; Onur Atasoylu; Emma Hodson; Anthony Tumber; Ivanhoe K H Leung; Rasheduzzaman Chowdhury; Verónica Gómez-Pérez; Marina Demetriades; Anna M Rydzik; James Holt-Martyn; Ya-Min Tian; Tammie Bishop; Timothy D W Claridge; Akane Kawamura; Christopher W Pugh; Peter J Ratcliffe; Christopher J Schofield
Journal:  PLoS One       Date:  2015-07-06       Impact factor: 3.240

Review 7.  Targeting histone lysine demethylases - progress, challenges, and the future.

Authors:  Cyrille C Thinnes; Katherine S England; Akane Kawamura; Rasheduzzaman Chowdhury; Christopher J Schofield; Richard J Hopkinson
Journal:  Biochim Biophys Acta       Date:  2014-05-21

8.  Kinetic parameters of human aspartate/asparagine-β-hydroxylase suggest that it has a possible function in oxygen sensing.

Authors:  Lennart Brewitz; Anthony Tumber; Christopher J Schofield
Journal:  J Biol Chem       Date:  2020-02-26       Impact factor: 5.157

9.  Studies on the selectivity of proline hydroxylases reveal new substrates including bicycles.

Authors:  Tristan J Smart; Refaat B Hamed; Timothy D W Claridge; Christopher J Schofield
Journal:  Bioorg Chem       Date:  2019-10-28       Impact factor: 5.275

10.  A study on the AMACR catalysed elimination reaction and its application to inhibitor testing.

Authors:  Maksims Yevglevskis; Guat L Lee; Jenny Sun; Shiyi Zhou; Xiaolong Sun; Gabriele Kociok-Köhn; Tony D James; Timothy J Woodman; Matthew D Lloyd
Journal:  Org Biomol Chem       Date:  2016-01-14       Impact factor: 3.876
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