BACKGROUND: Research has reported relationships between 3-dimensional (3D) radiation dose to head and neck structures and consequential swallowing/nutritional outcomes. However, this evidence is preliminary. The current study aimed to identify which reported dose constraints identified functional impairment at 6 months posttreatment. METHODS: Dose constraints with reported relationships to swallowing and nutrition were identified through a systematic literature review. Dose-volume histograms for 12 patients with T1-T3 oropharyngeal cancer treated with 3D conformal radiotherapy determined dosages delivered to specific structures. Doses were examined in relation to published dose constraints and the swallowing and nutritional outcomes at 6 months posttreatment. RESULTS: In all, 66% of the reported mean, maximum, and partial doses to 8 structures correctly identified swallowing and nutrition outcomes at 6 months. CONCLUSION: The relationships observed between known dosimetric constraints and functional outcomes highlight the potential for dosimetric data to assist in prognosis and treatment. Systematic research is required to refine dosimetric parameters and the impact on functional outcomes.
BACKGROUND: Research has reported relationships between 3-dimensional (3D) radiation dose to head and neck structures and consequential swallowing/nutritional outcomes. However, this evidence is preliminary. The current study aimed to identify which reported dose constraints identified functional impairment at 6 months posttreatment. METHODS: Dose constraints with reported relationships to swallowing and nutrition were identified through a systematic literature review. Dose-volume histograms for 12 patients with T1-T3 oropharyngeal cancer treated with 3D conformal radiotherapy determined dosages delivered to specific structures. Doses were examined in relation to published dose constraints and the swallowing and nutritional outcomes at 6 months posttreatment. RESULTS: In all, 66% of the reported mean, maximum, and partial doses to 8 structures correctly identified swallowing and nutrition outcomes at 6 months. CONCLUSION: The relationships observed between known dosimetric constraints and functional outcomes highlight the potential for dosimetric data to assist in prognosis and treatment. Systematic research is required to refine dosimetric parameters and the impact on functional outcomes.
Authors: Musaddiq J Awan; Abdallah S R Mohamed; Jan S Lewin; Charles A Baron; G Brandon Gunn; David I Rosenthal; F Christopher Holsinger; David L Schwartz; Clifton D Fuller; Katherine A Hutcheson Journal: Oral Oncol Date: 2014-06-03 Impact factor: 5.337
Authors: Mary E Platek; Elizabeth Myrick; Susan A McCloskey; Vishal Gupta; Mary E Reid; Gregory E Wilding; David Cohan; Hassan Arshad; Nestor R Rigual; Wesley L Hicks; Maureen Sullivan; Graham W Warren; Anurag K Singh Journal: Support Care Cancer Date: 2013-06-07 Impact factor: 3.603
Authors: Asha Mathew; Amit Jiwan Tirkey; Hongjin Li; Alana Steffen; Mark B Lockwood; Crystal L Patil; Ardith Z Doorenbos Journal: Semin Oncol Nurs Date: 2021-09-03 Impact factor: 3.527
Authors: Abdallah S R Mohamed; Houda Bahig; Michalis Aristophanous; Pierre Blanchard; Mona Kamal; Yao Ding; Carlos E Cardenas; Kristy K Brock; Stephen Y Lai; Katherine A Hutcheson; Jack Phan; Jihong Wang; Geoffrey Ibbott; Refaat E Gabr; Ponnada A Narayana; Adam S Garden; David I Rosenthal; G Brandon Gunn; Clifton D Fuller Journal: Clin Transl Radiat Oncol Date: 2018-05-05