Literature DB >> 22728136

Endothelin Converting Enzyme-1 phosphorylation and trafficking.

Sanjaya Kuruppu1, A Ian Smith.   

Abstract

Endothelin Converting Enzyme-1 (ECE-1) plays a significant role in the regulation of vascular tone and hence blood pressure. It has also been implicated in the pathogenesis of cardiovascular diseases, female malignancies and Alzheimer's disease. Four different isoforms of ECE-1 exist and have varying degrees of distribution throughout the cell. Production of ET-1 by ECE-1 occurs at the cell surface and the expression and localisation of ECE-1 is the rate limiting step in the production of ET-1. This review looks at the current knowledge on ECE-1 phosphorylation and other stimuli which act induce trafficking of ECE-1 to the cell surface. Crown
Copyright © 2012. Published by Elsevier B.V. All rights reserved.

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Year:  2012        PMID： 22728136     DOI： 10.1016/j.febslet.2012.06.020

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  8 in total

1.  Applicability of green fluorescence protein in the study of endothelin converting enzyme-1c trafficking.

Authors:  Sanjaya Kuruppu; Nathalie Tochon-Danguy; A Ian Smith
Journal:  Protein Sci       Date:  2013-02-01       Impact factor: 6.725

2.  Endothelin and vascular remodelling in colitis pathogenesis--appendicitis and appendectomy limit colitis by suppressing endothelin pathways.

Authors:  Rajkumar Cheluvappa; Rajaraman Eri; Annie S Luo; Michael C Grimm
Journal:  Int J Colorectal Dis       Date:  2014-08-02       Impact factor: 2.571

3.  Nitric oxide inhibits the production of soluble endothelin converting enzyme-1.

Authors:  Sanjaya Kuruppu; Niwanthi W Rajapakse; Rhys A Dunstan; A Ian Smith
Journal:  Mol Cell Biochem       Date:  2014-09-17       Impact factor: 3.396

4.  Cell-based screening identifies the active ingredients from Traditional Chinese Medicine formula Shixiao San as the inhibitors of atherosclerotic endothelial dysfunction.

Authors:  Xiaofan Wang; Ruowen Zhang; Liqiang Gu; Yuanyuan Zhang; Xu Zhao; Kaishun Bi; Xiaohui Chen
Journal:  PLoS One       Date:  2015-02-20       Impact factor: 3.240

5.  Colon cancer cell invasion is promoted by protein kinase CK2 through increase of endothelin-converting enzyme-1c protein stability.

Authors:  Ignacio Niechi; Eduardo Silva; Pablo Cabello; Hernan Huerta; Valentina Carrasco; Paulina Villar; Luis Rodrigo Cataldo; Katherine Marcelain; Ricardo Armisen; Manuel Varas-Godoy; Cristina Fernandez; Julio C Tapia
Journal:  Oncotarget       Date:  2015-12-15

6.  Association between ECE1 gene polymorphisms and risk of intracerebral haemorrhage.

Authors:  Yi Zeng; Mingming Ma; Baoqiong Liu; Jian Xia; Hongwei Xu; Yunhai Liu; Xiaoping Du; Zhiping Hu; Qidong Yang; Le Zhang
Journal:  J Int Med Res       Date:  2016-04-01       Impact factor: 1.671

Review 7.  Pharmacological hypothesis: Nitric oxide-induced inhibition of ADAM-17 activity as well as vesicle release can in turn prevent the production of soluble endothelin-converting enzyme.

Authors:  Sanjaya Kuruppu; Niwanthi W Rajapakse; Helena C Parkington; Ian Smith
Journal:  Pharmacol Res Perspect       Date:  2017-10

8.  Changes in vasoactive pathways in congenital diaphragmatic hernia associated pulmonary hypertension explain unresponsiveness to pharmacotherapy.

Authors:  Daphne S Mous; Marjon J Buscop-van Kempen; Rene M H Wijnen; Dick Tibboel; Robbert J Rottier
Journal:  Respir Res       Date:  2017-11-07
  8 in total

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