Literature DB >> 22726679

Unleashing a "true" pSer-mimic in the cell.

Kaushik Panigrahi1, David L Nelson, David B Berkowitz.   

Abstract

In this issue of Chemistry & Biology, Arrendale and coworkers demonstrate a new prodrug strategy for intracellular delivery of an α, α-(difluoromethylene)phosphonate phosphoserine mimic. The deprotected pseudo-phosphopeptide releases the pro-apoptotic FOXO3a-transcription factor from its 14-3-3-adaptor protein complex, resulting in leukemic cell death.
Copyright © 2012 Elsevier Ltd. All rights reserved.

Entities:  

Year:  2012        PMID： 22726679      PMCID： PMC4688326          DOI： 10.1016/j.chembiol.2012.06.005

Source DB:  PubMed          Journal:  Chem Biol        ISSN： 1074-5521


  7 in total

1.  Synthesis of a phosphoserine mimetic prodrug with potent 14-3-3 protein inhibitory activity.

Authors:  Allison Arrendale; Keunho Kim; Jun Young Choi; Wei Li; Robert L Geahlen; Richard F Borch
Journal:  Chem Biol       Date:  2012-06-22

2.  Ready Access to Fluorinated Phosphonate Mimics of Secondary Phosphates. Synthesis of the (alpha,alpha-Difluoroalkyl)phosphonate Analogues of L-Phosphoserine, L-Phosphoallothreonine, and L-Phosphothreonine.

Authors:  David B. Berkowitz; MariJean Eggen; Quanrong Shen; Richard K. Shoemaker
Journal:  J Org Chem       Date:  1996-07-12       Impact factor: 4.354

3.  Sequential activation and deactivation of protein function using spectrally differentiated caged phosphoamino acids.

Authors:  Brenda N Goguen; Andreas Aemissegger; Barbara Imperiali
Journal:  J Am Chem Soc       Date:  2011-06-29       Impact factor: 15.419

4.  Cellular stability of serotonin N-acetyltransferase conferred by phosphonodifluoromethylene alanine (Pfa) substitution for Ser-205.

Authors:  Weiping Zheng; Dirk Schwarzer; Aaron Lebeau; Joan L Weller; David C Klein; Philip A Cole
Journal:  J Biol Chem       Date:  2005-01-04       Impact factor: 5.157

5.  Crystal structure of the 14-3-3zeta:serotonin N-acetyltransferase complex. a role for scaffolding in enzyme regulation.

Authors:  T Obsil; R Ghirlando; D C Klein; S Ganguly; F Dyda
Journal:  Cell       Date:  2001-04-20       Impact factor: 41.582

Review 6.  The alpha,alpha-difluorinated phosphonate L-pSer-analogue: an accessible chemical tool for studying kinase-dependent signal transduction.

Authors:  Kaushik Panigrahi; MariJean Eggen; Jun-Ho Maeng; Quanrong Shen; David B Berkowitz
Journal:  Chem Biol       Date:  2009-09-25

7.  Regulation of CK2 by phosphorylation and O-GlcNAcylation revealed by semisynthesis.

Authors:  Mary Katherine Tarrant; Hee-Sool Rho; Zhi Xie; Yu Lin Jiang; Christopher Gross; Jeffrey C Culhane; Gai Yan; Jiang Qian; Yoshitaka Ichikawa; Tatsuji Matsuoka; Natasha Zachara; Felicia A Etzkorn; Gerald W Hart; Jun Seop Jeong; Seth Blackshaw; Heng Zhu; Philip A Cole
Journal:  Nat Chem Biol       Date:  2012-01-22       Impact factor: 15.040
  7 in total
  5 in total

Review 1.  Direct Activation of Bax Protein for Cancer Therapy.

Authors:  Zhiqing Liu; Ye Ding; Na Ye; Christopher Wild; Haiying Chen; Jia Zhou
Journal:  Med Res Rev       Date:  2015-09-23       Impact factor: 12.944

2.  Efficient delivery of cell impermeable phosphopeptides by a cyclic peptide amphiphile containing tryptophan and arginine.

Authors:  Amir Nasrolahi Shirazi; Rakesh Kumar Tiwari; Donghoon Oh; Antara Banerjee; Arpita Yadav; Keykavous Parang
Journal:  Mol Pharm       Date:  2013-04-15       Impact factor: 4.939

3.  Phosphatase-inert glucosamine 6-phosphate mimics serve as actuators of the glmS riboswitch.

Authors:  Xiang Fei; Thomas Holmes; Julianna Diddle; Lauren Hintz; Dan Delaney; Alex Stock; Danielle Renner; Molly McDevitt; David B Berkowitz; Juliane K Soukup
Journal:  ACS Chem Biol       Date:  2014-10-27       Impact factor: 5.100

4.  PermaPhos Ser : autonomous synthesis of functional, permanently phosphorylated proteins.

Authors:  Phillip Zhu; Rachel Franklin; Amber Vogel; Stanislau Stanisheuski; Patrick Reardon; Nikolai N Sluchanko; Joseph S Beckman; P Andrew Karplus; Ryan A Mehl; Richard B Cooley
Journal:  bioRxiv       Date:  2021-12-14

Review 5.  Phosphonopeptides containing free phosphonic groups: recent advances.

Authors:  Paweł Kafarski
Journal:  RSC Adv       Date:  2020-07-09       Impact factor: 4.036
  5 in total

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