Literature DB >> 22726585

Modular organization of the mammalian Golgi apparatus.

Nobuhiro Nakamura1, Jen-Hsuan Wei, Joachim Seemann.   

Abstract

The Golgi apparatus is essential for post-translational modifications and sorting of proteins in the secretory pathway. In addition, it further performs a broad range of specialized functions. This functional diversity is achieved by combining basic morphological modules of cisternae into higher ordered structures. Linking cisternae into stacks that are further connected through tubules into a continuous Golgi ribbon greatly increases its efficiency and expands its repertoire of functions. During cell division, the different modules of the Golgi are inherited by different mechanisms to maintain its functional and morphological composition.
Copyright © 2012 Elsevier Ltd. All rights reserved.

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Year:  2012        PMID： 22726585      PMCID： PMC3495003          DOI： 10.1016/j.ceb.2012.05.009

Source DB:  PubMed          Journal:  Curr Opin Cell Biol        ISSN： 0955-0674            Impact factor:   8.382


  97 in total

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