Literature DB >> 2272647

Hypoglycemic activity of Swertia chirayita (Roxb ex Flem) Karst.

B Chandrasekar1, M B Bajpai, S K Mukherjee.   

Abstract

Hexane fraction of S. chirayita (250 mg/kg body wt.) induced significant fall in blood sugar and significant increase in plasma IRI simultaneously after single oral administration without influencing liver glycogen concentration in albino rats. On the other hand, daily administration for 28 days resulted in significant lowering of blood sugar and increase in plasma IRI along with a significant rise in liver glycogen. Intestinal absorption of glucose was not inhibited by hexane fraction. It is suggested that hexane fraction of S. chirayita possibly acts through its insulin releasing effect.

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Year:  1990        PMID: 2272647

Source DB:  PubMed          Journal:  Indian J Exp Biol        ISSN: 0019-5189            Impact factor:   0.818


  7 in total

1.  Insights into mechanisms underlying the gut and airways modulatory effects of Swertia chirata.

Authors:  Arif-ullah Khan; Ashfaque Rahim; Zafar Iqbal; Anwarul-Hassan Gilani
Journal:  J Nat Med       Date:  2011-07-27       Impact factor: 2.343

2.  The effect of pulp and seed extract of Citrullus Colocynthis, as an antidaibetic medicinal herb, on hepatocytes glycogen stores in diabetic rabbits.

Authors:  Hajar Shafaei; Jafar Soleimani Rad; Abbas Delazar; Mohaddeseh Behjati
Journal:  Adv Biomed Res       Date:  2014-12-31

3.  An overview of Indian novel traditional medicinal plants with anti-diabetic potentials.

Authors:  Rahul Gupta; Kumar Gaurav Bajpai; Samta Johri; A M Saxena
Journal:  Afr J Tradit Complement Altern Med       Date:  2007-10-27

4.  Medicinal chemistry of the anti-diabetic effects of momordica charantia: active constituents and modes of actions.

Authors:  Jaipaul Singh; Emmanuel Cumming; Gunasekar Manoharan; Huba Kalasz; Ernest Adeghate
Journal:  Open Med Chem J       Date:  2011-09-09

5.  Clinical efficacy of Mehamudgara vati in type 2 diabetes mellitus.

Authors:  Ila Tanna; H M Chandola; J R Joshi
Journal:  Ayu       Date:  2011-01

6.  Identification of PPARgamma partial agonists of natural origin (II): in silico prediction in natural extracts with known antidiabetic activity.

Authors:  Laura Guasch; Esther Sala; Miquel Mulero; Cristina Valls; Maria Josepa Salvadó; Gerard Pujadas; Santiago Garcia-Vallvé
Journal:  PLoS One       Date:  2013-02-06       Impact factor: 3.240

7.  Evaluation of anti-diabetic activity of Glucova Active Tablet on Type I and Type II diabetic model in rats.

Authors:  Hardik Soni; Sejal Patel; Ghanshyam Patel; Archana Paranjape
Journal:  J Ayurveda Integr Med       Date:  2014-04
  7 in total

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