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Literature DB >> 22726083

How I treat inhibitors in haemophilia.

M Makris¹, C R M Hay, A Gringeri, R D'Oiron.

Abstract

The management of patients with inhibitors is the greatest challenge facing haemophilia health professionals. Immune tolerance induction (ITI) can be successful in eliminating the inhibitor in the majority of patients, provided it is started soon after the inhibitor develops and the titre of the inhibitor is <10 BU at commencement of ITI. Acute bleeding is treated using one of two bypassing agents, which exhibit similar efficacy and safety. Surgery in inhibitor patients is challenging and should only be carried out in experienced centres.

Entities: Disease Species

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Year: 2012 PMID： 22726083 DOI： 10.1111/j.1365-2516.2012.02829.x

Source DB: PubMed Journal: Haemophilia ISSN： 1351-8216 Impact factor: 4.287

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Cited

5 in total

1. Skin testing, graded challenge, and desensitization to von Willebrand factor (VWF) products in type III von Willebrand disease (VWD).

Authors: Craig D Platt; Loren D'Angelo; Ellis J Neufeld; Ana Dioun Broyles
Journal: J Allergy Clin Immunol Pract Date: 2016-07-09

How I treat inhibitors in haemophilia.

1. Skin testing, graded challenge, and desensitization to von Willebrand factor (VWF) products in type III von Willebrand disease (VWD).

Review 2. Laboratory testing for factor VIII and IX inhibitors in haemophilia: A review.

3. Successful Desensitization of a Patient with Possible IgE-Mediated Anaphylactic Reaction to FVIII/VWF Concentrate.

Review 4. Current animal models of hemophilia: the state of the art.

Review 5. Treatment and Prevention of Bleeds in Haemophilia Patients with Inhibitors to Factor VIII/IX.