OBJECTIVE: This study examined whether carotid artery intimal-medial thickness (cIMT) is associated with genetic variations (SNPs) in a hemodynamics-responsive gene pathway. METHODS: Subjects were Cardiovascular Health Study participants free of cardiovascular events at baseline (N=3388). Genotype was measured using Illumina 370CNV HumanHap chip. Carotid IMT was measured using ultrasound. Estimated mean differences in cIMT per additional minor allele for 366 SNPs in MAP2K5, MAPK7, MEF2A/C, and KLF2 were adjusted for sex, age, clinic, and medication use. SNP-SNP interactions were examined using logic regression for 71 tagSNPs. RESULTS: None of the associations was significant after correction for multiple comparisons; smallest P-value=0.065 for MAP2K5 and common cIMT. The best-performing logic regression tree combined two SNPs in MAP2K5-rs745212 and rs12905175- and common cIMT; this association was not significant, corrected P-value=0.062. CONCLUSION: There was not strong evidence of association between genetic variants in a hemodynamics-responsive gene pathway and atherosclerosis among older adults.
OBJECTIVE: This study examined whether carotid artery intimal-medial thickness (cIMT) is associated with genetic variations (SNPs) in a hemodynamics-responsive gene pathway. METHODS: Subjects were Cardiovascular Health Study participants free of cardiovascular events at baseline (N=3388). Genotype was measured using Illumina 370CNV HumanHap chip. Carotid IMT was measured using ultrasound. Estimated mean differences in cIMT per additional minor allele for 366 SNPs in MAP2K5, MAPK7, MEF2A/C, and KLF2 were adjusted for sex, age, clinic, and medication use. SNP-SNP interactions were examined using logic regression for 71 tagSNPs. RESULTS: None of the associations was significant after correction for multiple comparisons; smallest P-value=0.065 for MAP2K5 and common cIMT. The best-performing logic regression tree combined two SNPs in MAP2K5-rs745212 and rs12905175- and common cIMT; this association was not significant, corrected P-value=0.062. CONCLUSION: There was not strong evidence of association between genetic variants in a hemodynamics-responsive gene pathway and atherosclerosis among older adults.
Authors: Kush M Parmar; H Benjamin Larman; Guohao Dai; Yuzhi Zhang; Eric T Wang; Sripriya N Moorthy; Johannes R Kratz; Zhiyong Lin; Mukesh K Jain; Michael A Gimbrone; Guillermo García-Cardeña Journal: J Clin Invest Date: 2005-12-08 Impact factor: 14.808
Authors: L P Fried; N O Borhani; P Enright; C D Furberg; J M Gardin; R A Kronmal; L H Kuller; T A Manolio; M B Mittelmark; A Newman Journal: Ann Epidemiol Date: 1991-02 Impact factor: 3.797
Authors: Christopher Newton-Cheh; Mark Eijgelsheim; Kenneth M Rice; Paul I W de Bakker; Xiaoyan Yin; Karol Estrada; Joshua C Bis; Kristin Marciante; Fernando Rivadeneira; Peter A Noseworthy; Nona Sotoodehnia; Nicholas L Smith; Jerome I Rotter; Jan A Kors; Jacqueline C M Witteman; Albert Hofman; Susan R Heckbert; Christopher J O'Donnell; André G Uitterlinden; Bruce M Psaty; Thomas Lumley; Martin G Larson; Bruno H Ch Stricker Journal: Nat Genet Date: 2009-03-22 Impact factor: 38.330
Authors: Michael A Rosenberg; Robert C Kaplan; David S Siscovick; Bruce M Psaty; Susan R Heckbert; Christopher Newton-Cheh; Kenneth J Mukamal Journal: Am J Epidemiol Date: 2014-06-18 Impact factor: 4.897