Literature DB >> 2272349

Non-peptide angiotensin II receptor antagonists discriminate subtypes of 125I-angiotensin II binding sites in the rat brain.

D R Gehlert1, S L Gackenheimer, J K Reel, H S Lin, M I Steinberg.   

Abstract

We have utilized quantitative autoradiography to define subtypes of 125I-angiotensin II (AII) binding in rat brain. AII-1 binding (displaced by DuP 753) was found in the nucleus of the solitary tract and the hypothalamus, while AII-2 binding (displaced by WL 19) was found in the thalamus and lateral septum. These results indicate that subtypes of the AII receptor are present in the brain and the AII-1 receptor subtype is present in regions consistant with the known actions of angiotensin.

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Year:  1990        PMID： 2272349     DOI： 10.1016/0014-2999(90)90348-a

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  9 in total

1.  Effect of luminal angiotensin II receptor antagonists on proximal tubule transport.

Authors:  A Quan; M Baum
Journal:  Am J Hypertens       Date:  1999-05       Impact factor: 2.689

2.  Pharmacological characterization of angiotensin II AT(2) receptor subtype heterogeneity in the rat adrenal cortex and medulla.

Authors:  X Lu; K L Grove; W Zhang; R C Speth
Journal:  Endocrine       Date:  1995-04       Impact factor: 3.633

3.  Effects of the selective angiotensin II receptor antagonists losartan and PD123177 in animal models of anxiety and memory.

Authors:  J Shepherd; D J Bill; C T Dourish; S S Grewal; A McLenachan; K J Stanhope
Journal:  Psychopharmacology (Berl)       Date:  1996-08       Impact factor: 4.530

4.  Functional interaction between losartan and central tachykinin NK3 receptors in the conscious rat.

Authors:  P Picard; L Chrétien; R Couture
Journal:  Br J Pharmacol       Date:  1995-04       Impact factor: 8.739

5.  Angiotensin II receptor subtypes are coupled with distinct signal-transduction mechanisms in neurons and astrocytes from rat brain.

Authors:  C Sumners; W Tang; B Zelezna; M K Raizada
Journal:  Proc Natl Acad Sci U S A       Date:  1991-09-01       Impact factor: 11.205

Review 6.  Angiotensin converting enzyme inhibitors as potential cognitive enhancing agents.

Authors:  A M Domeney
Journal:  J Psychiatry Neurosci       Date:  1994-01       Impact factor: 6.186

7.  DuP 753, a nonpeptide angiotensin II-1 receptor antagonist, alters dopaminergic function in rat striatum.

Authors:  L P Dwoskin; A L Jewell; L A Cassis
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1992-02       Impact factor: 3.000

8.  Access of peripherally administered DuP 753 to rat brain angiotensin II receptors.

Authors:  K F Song; J L Zhuo; F A Mendelsohn
Journal:  Br J Pharmacol       Date:  1991-12       Impact factor: 8.739

Review 9.  Recent Advances in the Endogenous Brain Renin-Angiotensin System and Drugs Acting on It.

Authors:  Aswar Urmila; Patil Rashmi; Ghag Nilam; Bodhankar Subhash
Journal:  J Renin Angiotensin Aldosterone Syst       Date:  2021-11-30       Impact factor: 1.636
  9 in total

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