Literature DB >> 22723461

Resurrecting DNAzymes as sequence-specific therapeutics.

John J Rossi1.   

Abstract

In a mouse model of skin cancer, intratumoral injection of a sequence-specific mRNA-cleaving DNA enzyme caused potent inhibition of tumor growth and unusually benign pharmacodynamic profiles.

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Year:  2012        PMID： 22723461     DOI： 10.1126/scitranslmed.3004080

Source DB:  PubMed          Journal:  Sci Transl Med        ISSN： 1946-6234            Impact factor:   17.956


  2 in total

1.  Antiangiogenic and antitumoral effects mediated by a vascular endothelial growth factor receptor 1 (VEGFR-1)-targeted DNAzyme.

Authors:  Liangfang Shen; Qin Zhou; Ying Wang; Weihua Liao; Yan Chen; Zhijie Xu; Lifang Yang; Lun-Quan Sun
Journal:  Mol Med       Date:  2013-11-08       Impact factor: 6.354

2.  Destroying c-jun Messenger: new insights into biological mechanisms of DNAzyme function.

Authors:  Levon M Khachigian; Hong Cai; Fergal J Moloney; Christopher R Parish; Beng H Chong; Roland Stocker; Ross St C Barnetson; Gary M Halliday
Journal:  Oncotarget       Date:  2012-06
  2 in total

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