Literature DB >> 22722395

Tumorigenesis. Better by half.

Nicola McCarthy.   

Abstract

This paper suggests that recurrent regions of somatic hemizygosity might exist in tumours because they enable a reduction in the expression levels of genes that restrict cell proliferation and survival, and minimize the loss of genes that are essential for cell survival.

Entities:  

Year:  2012        PMID： 22722395     DOI： 10.1038/nrc3307

Source DB:  PubMed          Journal:  Nat Rev Cancer        ISSN： 1474-175X            Impact factor:   60.716


  1 in total

1.  Recurrent hemizygous deletions in cancers may optimize proliferative potential.

Authors:  Nicole L Solimini; Qikai Xu; Craig H Mermel; Anthony C Liang; Michael R Schlabach; Ji Luo; Anna E Burrows; Anthony N Anselmo; Andrea L Bredemeyer; Mamie Z Li; Rameen Beroukhim; Matthew Meyerson; Stephen J Elledge
Journal:  Science       Date:  2012-05-24       Impact factor: 47.728
  1 in total
  1 in total

1.  Integrated Genomics for Pinpointing Survival Loci within Arm-Level Somatic Copy Number Alterations.

Authors:  David M Roy; Logan A Walsh; Alexis Desrichard; Jason T Huse; Wei Wu; JianJiong Gao; Promita Bose; William Lee; Timothy A Chan
Journal:  Cancer Cell       Date:  2016-05-09       Impact factor: 31.743
  1 in total

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