Literature DB >> 22722338

Metformin pathways: pharmacokinetics and pharmacodynamics.

Li Gong1, Srijib Goswami, Kathleen M Giacomini, Russ B Altman, Teri E Klein.   

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Year:  2012        PMID： 22722338      PMCID： PMC3651676          DOI： 10.1097/FPC.0b013e3283559b22

Source DB:  PubMed          Journal:  Pharmacogenet Genomics        ISSN： 1744-6872            Impact factor:   2.089


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  62 in total

1.  Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain.

Authors:  M R Owen; E Doran; A P Halestrap
Journal:  Biochem J       Date:  2000-06-15       Impact factor: 3.857

2.  The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin.

Authors:  M V Tzvetkov; S V Vormfelde; D Balen; I Meineke; T Schmidt; D Sehrt; I Sabolić; H Koepsell; J Brockmöller
Journal:  Clin Pharmacol Ther       Date:  2009-06-17       Impact factor: 6.875

3.  Metformin suppresses pregnane X receptor (PXR)-regulated transactivation of CYP3A4 gene.

Authors:  Lucie Krausova; Lucie Stejskalova; Hongwei Wang; Radim Vrzal; Zdenek Dvorak; Sridhar Mani; Petr Pavek
Journal:  Biochem Pharmacol       Date:  2011-09-06       Impact factor: 5.858

4.  Mechanism by which metformin reduces glucose production in type 2 diabetes.

Authors:  R S Hundal; M Krssak; S Dufour; D Laurent; V Lebon; V Chandramouli; S E Inzucchi; W C Schumann; K F Petersen; B R Landau; G I Shulman
Journal:  Diabetes       Date:  2000-12       Impact factor: 9.461

Review 5.  Organic cation transporters (OCTs, MATEs), in vitro and in vivo evidence for the importance in drug therapy.

Authors:  Anne T Nies; Hermann Koepsell; Katja Damme; Matthias Schwab
Journal:  Handb Exp Pharmacol       Date:  2011

6.  The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level.

Authors:  I Ben Sahra; K Laurent; A Loubat; S Giorgetti-Peraldi; P Colosetti; P Auberger; J F Tanti; Y Le Marchand-Brustel; F Bost
Journal:  Oncogene       Date:  2008-01-21       Impact factor: 9.867

7.  Genetic variants of the organic cation transporter 2 influence the disposition of metformin.

Authors:  I S Song; H J Shin; E J Shim; I S Jung; W Y Kim; J H Shon; J G Shin
Journal:  Clin Pharmacol Ther       Date:  2008-04-09       Impact factor: 6.875

8.  Interaction of oral antidiabetic drugs with hepatic uptake transporters: focus on organic anion transporting polypeptides and organic cation transporter 1.

Authors:  Iouri Bachmakov; Hartmut Glaeser; Martin F Fromm; Jörg König
Journal:  Diabetes       Date:  2008-02-26       Impact factor: 9.461

9.  Targeted disruption of the multidrug and toxin extrusion 1 (mate1) gene in mice reduces renal secretion of metformin.

Authors:  Masahiro Tsuda; Tomohiro Terada; Tomoyuki Mizuno; Toshiya Katsura; Jin Shimakura; Ken-ichi Inui
Journal:  Mol Pharmacol       Date:  2009-03-30       Impact factor: 4.436

10.  Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program.

Authors:  Kathleen A Jablonski; Jarred B McAteer; Paul I W de Bakker; Paul W Franks; Toni I Pollin; Robert L Hanson; Richa Saxena; Sarah Fowler; Alan R Shuldiner; William C Knowler; David Altshuler; Jose C Florez
Journal:  Diabetes       Date:  2010-08-03       Impact factor: 9.461
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  119 in total

Review 1.  The pharmacogenetics of metformin.

Authors:  Jose C Florez
Journal:  Diabetologia       Date:  2017-08-03       Impact factor: 10.122

Review 2.  Potential applications for biguanides in oncology.

Authors:  Michael Pollak
Journal:  J Clin Invest       Date:  2013-09-03       Impact factor: 14.808

3.  Endogenous glucose production increases in response to metformin treatment in the glycogen-depleted state in humans: a randomised trial.

Authors:  Mette Marie H Christensen; Kurt Højlund; Ole Hother-Nielsen; Tore B Stage; Per Damkier; Henning Beck-Nielsen; Kim Brøsen
Journal:  Diabetologia       Date:  2015-08-14       Impact factor: 10.122

4.  Effects of Pregnancy on the Pharmacokinetics of Metformin.

Authors:  Michael Z Liao; Shannon K Flood Nichols; Mahmoud Ahmed; Shannon Clark; Gary D Hankins; Steve Caritis; Raman Venkataramanan; David Haas; Sara K Quinney; Laura S Haneline; Alan T Tita; Tracy Manuck; Joanne Wang; Kenneth E Thummel; Linda Morris Brown; Zhaoxia Ren; Thomas R Easterling; Mary F Hebert
Journal:  Drug Metab Dispos       Date:  2020-01-24       Impact factor: 3.922

5.  Using EHR-Linked Biobank Data to Study Metformin Pharmacogenomics.

Authors:  Matthew K Breitenstein; Gyorgy Simon; Euijung Ryu; Sebastian M Armasu; Richard M Weinshilboum; Liewei Wang; Jyotishman Pathak
Journal:  Stud Health Technol Inform       Date:  2015

6.  Effects of SLC22A1 Polymorphisms on Metformin-Induced Reductions in Adiposity and Metformin Pharmacokinetics in Obese Children With Insulin Resistance.

Authors:  Wai Johnn Sam; Orsolya Roza; Yuen Yi Hon; Raul M Alfaro; Karim A Calis; James C Reynolds; Jack A Yanovski
Journal:  J Clin Pharmacol       Date:  2016-08-23       Impact factor: 3.126

Review 7.  Diabetes treatment in patients with renal disease: Is the landscape clear enough?

Authors:  Ioannis Ioannidis
Journal:  World J Diabetes       Date:  2014-10-15

8.  The Antidiabetic Drug Metformin Stimulates Glycolytic Lactate Production in Cultured Primary Rat Astrocytes.

Authors:  Adrian Westhaus; Eva Maria Blumrich; Ralf Dringen
Journal:  Neurochem Res       Date:  2015-10-03       Impact factor: 3.996

9.  Pharmacological activation of AMPK inhibits incision-evoked mechanical hypersensitivity and the development of hyperalgesic priming in mice.

Authors:  Michael D Burton; Dipti V Tillu; Khadijah Mazhar; Galo L Mejia; Marina N Asiedu; Kufreobong Inyang; Travis Hughes; Bo Lian; Gregory Dussor; Theodore J Price
Journal:  Neuroscience       Date:  2017-07-17       Impact factor: 3.590

10.  The Effect of Famotidine, a MATE1-Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin.

Authors:  Jennifer E Hibma; Arik A Zur; Richard A Castro; Matthias B Wittwer; Ron J Keizer; Sook Wah Yee; Srijib Goswami; Sophie L Stocker; Xuexiang Zhang; Yong Huang; Claire M Brett; Radojka M Savic; Kathleen M Giacomini
Journal:  Clin Pharmacokinet       Date:  2016-06       Impact factor: 6.447
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