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Literature DB >> 22720681

Neurological disorders: towards a mechanistic understanding of restless legs syndrome.

Abstract

Restless legs syndrome is a curious neurological disorder of unknown aetiology. A new study has found that Drosophila mutants in the fly homologue of a human gene, BTBD9, that has been implicated as a risk factor for restless legs display important features of the syndrome.

Entities: CellLine Chemical Disease Gene Species

Mesh：

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Year: 2012 PMID： 22720681 PMCID： PMC3741047 DOI： 10.1016/j.cub.2012.05.004

Source DB: PubMed Journal: Curr Biol ISSN： 0960-9822 Impact factor: 10.834

14 in total

1. Evidence continues to mount on the relationship of restless legs syndrome/ periodic limb movements in sleep to hypertension, cardiovascular disease, and stroke.

Authors: Arthur S Walters; David B Rye
Journal: Sleep Date: 2010-03 Impact factor: 5.849

Review 2. Restless legs syndrome: pathophysiology, clinical presentation and management.

Authors: Claudia Trenkwalder; Walter Paulus
Journal: Nat Rev Neurol Date: 2010-06 Impact factor: 42.937

3. A genetic risk factor for periodic limb movements in sleep.

Authors: Hreinn Stefansson; David B Rye; Andrew Hicks; Hjorvar Petursson; Andres Ingason; Thorgeir E Thorgeirsson; Stefan Palsson; Thordur Sigmundsson; Albert P Sigurdsson; Ingibjorg Eiriksdottir; Emilia Soebech; Donald Bliwise; Joseph M Beck; Ami Rosen; Salina Waddy; Lynn M Trotti; Alex Iranzo; Madhav Thambisetty; Gudmundur A Hardarson; Kristleifur Kristjansson; Larus J Gudmundsson; Unnur Thorsteinsdottir; Augustine Kong; Jeffrey R Gulcher; Daniel Gudbjartsson; Kari Stefansson
Journal: N Engl J Med Date: 2007-07-18 Impact factor: 91.245

4. Restless legs syndrome-associated MEIS1 risk variant influences iron homeostasis.

Authors: Hélène Catoire; Patrick A Dion; Lan Xiong; Mourabit Amari; Rebecca Gaudet; Simon L Girard; Anne Noreau; Claudia Gaspar; Gustavo Turecki; Jacques Y Montplaisir; J Alex Parker; Guy A Rouleau
Journal: Ann Neurol Date: 2011-06-27 Impact factor: 10.422

Review 5. Restless legs syndrome: revisiting the dopamine hypothesis from the spinal cord perspective.

Authors: Stefan Clemens; David Rye; Shawn Hochman
Journal: Neurology Date: 2006-07-11 Impact factor: 9.910

6. Association studies of variants in MEIS1, BTBD9, and MAP2K5/SKOR1 with restless legs syndrome in a US population.

Authors: Qinbo Yang; Lin Li; Qiuyun Chen; Nancy Foldvary-Schaefer; William G Ondo; Qing Kenneth Wang
Journal: Sleep Med Date: 2011-09 Impact factor: 3.492

7. Functional screening of Alzheimer pathology genome-wide association signals in Drosophila.

Authors: Joshua M Shulman; Portia Chipendo; Lori B Chibnik; Cristin Aubin; Dong Tran; Brendan T Keenan; Patricia L Kramer; Julie A Schneider; David A Bennett; Mel B Feany; Philip L De Jager
Journal: Am J Hum Genet Date: 2011-02-03 Impact factor: 11.025

Neurological disorders: towards a mechanistic understanding of restless legs syndrome.

1. Evidence continues to mount on the relationship of restless legs syndrome/ periodic limb movements in sleep to hypertension, cardiovascular disease, and stroke.

Review 2. Restless legs syndrome: pathophysiology, clinical presentation and management.

3. A genetic risk factor for periodic limb movements in sleep.

4. Restless legs syndrome-associated MEIS1 risk variant influences iron homeostasis.

Review 5. Restless legs syndrome: revisiting the dopamine hypothesis from the spinal cord perspective.

6. Association studies of variants in MEIS1, BTBD9, and MAP2K5/SKOR1 with restless legs syndrome in a US population.

7. Functional screening of Alzheimer pathology genome-wide association signals in Drosophila.

Review 8. Genetics of sleep and sleep disorders.

9. Effects of immobility on sensory and motor symptoms of restless legs syndrome.

10. The transcriptional repressor DEC2 regulates sleep length in mammals.

Review 1. Restless Legs Syndrome: From Pathophysiology to Clinical Diagnosis and Management.