| Literature DB >> 22718563 |
Yu-Long Sun1, Bing-Jie Yang, Sean Xiao-An Zhang, Ying-Wei Yang.
Abstract
Light relief! Mesoporous silica materials equipped with photoresponsive cucurbit[7]uril-pseudorotaxane nanovalves operate in biological media to trap cargo molecules within nanopores, but undergo controlled release when irradiated with light of a suitable wavelength (see figure). Significantly, a "ladder"-release pattern is obtained to balance maximal therapeutic efficacy and minimal dose frequency in the development of "pulsed" drug therapy.Entities:
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Year: 2012 PMID： 22718563 DOI： 10.1002/chem.201201083
Source DB: PubMed Journal: Chemistry ISSN： 0947-6539 Impact factor: 5.236