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Literature DB >> 22717771

Lymph node vascular-stromal growth and function as a potential target for controlling immunity.

Fairouz Benahmed¹, Scott Ely, Theresa T Lu.

Abstract

Lymphadenopathy occurs in many autoimmune and inflammatory diseases, and vascular proliferation is a common feature in the enlarged lymph nodes. The lymph node vasculature plays critical roles in delivering immune cells as well as oxygen and micronutrients, and therefore represents a potential target for therapeutic manipulation of immunity. In this review, we discuss recent insights made in understanding the growth and function of the vascular and associated stromal compartment in immune-stimulated lymph nodes and the potential utility of altering this process in autoimmune diseases.

Entities: Chemical Disease Gene Species

Mesh：

Year: 2012 PMID： 22717771 PMCID： PMC3932544 DOI： 10.1016/j.clim.2012.05.004

Source DB: PubMed Journal: Clin Immunol ISSN： 1521-6616 Impact factor: 3.969

57 in total

Review 1. Homing and cellular traffic in lymph nodes.

Authors: Ulrich H von Andrian; Thorsten R Mempel
Journal: Nat Rev Immunol Date: 2003-11 Impact factor: 53.106

Review 2. Sphingosine-1-phosphate and lymphocyte egress from lymphoid organs.

Authors: Jason G Cyster; Susan R Schwab
Journal: Annu Rev Immunol Date: 2011-12-05 Impact factor: 28.527

3. Coordinated regulation of lymph node vascular-stromal growth first by CD11c+ cells and then by T and B cells.

Authors: Susan Chyou; Fairouz Benahmed; Jingfeng Chen; Varsha Kumar; Sha Tian; Martin Lipp; Theresa T Lu
Journal: J Immunol Date: 2011-10-26 Impact factor: 5.422

4. Reactive follicular hyperplasia in the lymph node lesions from systemic lupus erythematosus patients: a clinicopathological and immunohistological study of 21 cases.

Authors: M Kojima; S Nakamura; Y Morishita; H Itoh; K Yoshida; Y Ohno; T Oyama; S Asano; T Joshita; S Mori; T Suchi; N Masawa
Journal: Pathol Int Date: 2000-04 Impact factor: 2.534

5. Increased plasma cell frequency and accumulation of abnormal syndecan-1plus T-cells in Igmu-deficient/lpr mice.

Authors: Jane Seagal; Nira Leider; Gizi Wildbaum; Nathan Karin; Doron Melamed
Journal: Int Immunol Date: 2003-09 Impact factor: 4.823

6. Spectrum of lymph node pathology in adult onset Still's disease; analysis of 12 patients with one follow up biopsy.

Authors: Y K Jeon; J H Paik; S-S Park; S O Park; Y A Kim; J E Kim; Y W Song; C W Kim
Journal: J Clin Pathol Date: 2004-10 Impact factor: 3.411

7. Frequency of lymphadenopathy in rheumatoid arthritis and systemic lupus erythematosus.

Authors: M Calgüneri; M A Oztürk; Z Ozbalkan; A Akdogan; K Ureten; S Kiraz; I Ertenli
Journal: J Int Med Res Date: 2003 Jul-Aug Impact factor: 1.671

8. Regulation of T cell priming by lymphoid stroma.

Authors: Omar Khan; Mark Headley; Audrey Gerard; Wei Wei; Limin Liu; Matthew F Krummel
Journal: PLoS One Date: 2011-11-14 Impact factor: 3.240

9. Normalization of the lymph node T cell stromal microenvironment in lpr/lpr mice is associated with SU5416-induced reduction in autoantibodies.

Authors: Susan Chyou; Sha Tian; Eric H Ekland; Theresa T Lu
Journal: PLoS One Date: 2012-03-06 Impact factor: 3.240

10. Fibroblastic reticular cells from lymph nodes attenuate T cell expansion by producing nitric oxide.

Authors: Stefanie Siegert; Hsin-Ying Huang; Chen-Ying Yang; Leonardo Scarpellino; Lucie Carrie; Sarah Essex; Peter J Nelson; Matthias Heikenwalder; Hans Acha-Orbea; Christopher D Buckley; Benjamin J Marsland; Dietmar Zehn; Sanjiv A Luther
Journal: PLoS One Date: 2011-11-14 Impact factor: 3.240

7 in total

1. The CD68(+)/H-ferritin(+) cells colonize the lymph nodes of the patients with adult onset Still's disease and are associated with increased extracellular level of H-ferritin in the same tissue: correlation with disease severity and implication for pathogenesis.

Authors: P Ruscitti; F Ciccia; P Cipriani; G Guggino; P Di Benedetto; A Rizzo; V Liakouli; O Berardicurti; F Carubbi; G Triolo; R Giacomelli
Journal: Clin Exp Immunol Date: 2015-12-08 Impact factor: 4.330

Review 2. Regulation of Lymph Node Vascular-Stromal Compartment by Dendritic Cells.

Authors: Dragos C Dasoveanu; William D Shipman; Jennifer J Chia; Susan Chyou; Theresa T Lu
Journal: Trends Immunol Date: 2016-09-13 Impact factor: 16.687

3. Multiple CD11c+ cells collaboratively express IL-1β to modulate stromal vascular endothelial growth factor and lymph node vascular-stromal growth.

Authors: Fairouz Benahmed; Susan Chyou; Dragos Dasoveanu; Jingfeng Chen; Varsha Kumar; Yoichiro Iwakura; Theresa T Lu
Journal: J Immunol Date: 2014-03-21 Impact factor: 5.422

4. Optical projection tomography reveals dynamics of HEV growth after immunization with protein plus CFA and features shared with HEVs in acute autoinflammatory lymphadenopathy.

Authors: Varsha Kumar; Susan Chyou; Jens V Stein; Theresa T Lu
Journal: Front Immunol Date: 2012-09-07 Impact factor: 7.561