UNLABELLED: Although exercise can significantly reduce the prevalence and severity of diabetic complications, no studies have evaluated the impact of exercise on nerve function in people with diagnosed diabetic peripheral neuropathy (DPN). The purpose of this pilot study was to examine feasibility and effectiveness of a supervised, moderately intense aerobic and resistance exercise program in people with DPN. We hypothesized that the exercise intervention can improve neuropathic symptoms, nerve function, and cutaneous innervation. METHODS: A pre-test post-test design was used to assess change in outcome measures following participation in a 10-week aerobic and strengthening exercise program. Seventeen subjects with diagnosed DPN (8 males/9 females; age 58.4±5.98; duration of diabetes 12.4±12.2 years) completed the study. Outcome measures included pain measures (visual analog scale), Michigan Neuropathy Screening Instrument (MNSI) questionnaire of neuropathic symptoms, nerve function measures, and intraepidermal nerve fiber (IENF) density and branching in distal and proximal lower extremity skin biopsies. RESULTS: Significant reductions in pain (-18.1±35.5 mm on a 100 mm scale, P=.05), neuropathic symptoms (-1.24±1.8 on MNSI, P=.01), and increased intraepidermal nerve fiber branching (+0.11±0.15 branch nodes/fiber, P=.008) from a proximal skin biopsy were noted following the intervention. CONCLUSIONS: This is the first study to describe improvements in neuropathic and cutaneous nerve fiber branching following supervised exercise in people with diabetic peripheral neuropathy. These findings are particularly promising given the short duration of the intervention, but need to be validated by comparison with a control group in future studies.
UNLABELLED: Although exercise can significantly reduce the prevalence and severity of diabetic complications, no studies have evaluated the impact of exercise on nerve function in people with diagnosed diabetic peripheral neuropathy (DPN). The purpose of this pilot study was to examine feasibility and effectiveness of a supervised, moderately intense aerobic and resistance exercise program in people with DPN. We hypothesized that the exercise intervention can improve neuropathic symptoms, nerve function, and cutaneous innervation. METHODS: A pre-test post-test design was used to assess change in outcome measures following participation in a 10-week aerobic and strengthening exercise program. Seventeen subjects with diagnosed DPN (8 males/9 females; age 58.4±5.98; duration of diabetes 12.4±12.2 years) completed the study. Outcome measures included pain measures (visual analog scale), Michigan Neuropathy Screening Instrument (MNSI) questionnaire of neuropathic symptoms, nerve function measures, and intraepidermal nerve fiber (IENF) density and branching in distal and proximal lower extremity skin biopsies. RESULTS: Significant reductions in pain (-18.1±35.5 mm on a 100 mm scale, P=.05), neuropathic symptoms (-1.24±1.8 on MNSI, P=.01), and increased intraepidermal nerve fiber branching (+0.11±0.15 branch nodes/fiber, P=.008) from a proximal skin biopsy were noted following the intervention. CONCLUSIONS: This is the first study to describe improvements in neuropathic and cutaneous nerve fiber branching following supervised exercise in people with diabetic peripheral neuropathy. These findings are particularly promising given the short duration of the intervention, but need to be validated by comparison with a control group in future studies.
Authors: Giuseppe Lauria; Mayienne Bakkers; Christoph Schmitz; Raffaella Lombardi; Paola Penza; Grazia Devigili; A Gordon Smith; Sung-Tsieh Hsieh; Svein I Mellgren; Thirugnanam Umapathi; Dan Ziegler; Catharina G Faber; Ingemar S J Merkies Journal: J Peripher Nerv Syst Date: 2010-09 Impact factor: 3.494
Authors: Chang Ho Song; Jerrold S Petrofsky; Seung Won Lee; Kyoung Jin Lee; Jong Eun Yim Journal: Diabetes Technol Ther Date: 2011-05-11 Impact factor: 6.118
Authors: A Maiorana; G O'Driscoll; C Cheetham; L Dembo; K Stanton; C Goodman; R Taylor; D Green Journal: J Am Coll Cardiol Date: 2001-09 Impact factor: 24.094
Authors: Yuri Agrawal; John P Carey; Charles C Della Santina; Michael C Schubert; Lloyd B Minor Journal: Otol Neurotol Date: 2010-12 Impact factor: 2.311
Authors: Peter J Dyck; James W Albers; Henning Andersen; Joseph C Arezzo; Geert-Jan Biessels; Vera Bril; Eva L Feldman; William J Litchy; Peter C O'Brien; James W Russell Journal: Diabetes Metab Res Rev Date: 2011-10 Impact factor: 4.876
Authors: William C Knowler; Elizabeth Barrett-Connor; Sarah E Fowler; Richard F Hamman; John M Lachin; Elizabeth A Walker; David M Nathan Journal: N Engl J Med Date: 2002-02-07 Impact factor: 91.245
Authors: J Matt McCrary; David Goldstein; Carolina X Sandler; Benjamin K Barry; Michael Marthick; Hannah C Timmins; Tiffany Li; Lisa Horvath; Peter Grimison; Susanna B Park Journal: Support Care Cancer Date: 2019-02-12 Impact factor: 3.603
Authors: Roger J Paxton; Caitlin Feldman-Kothe; Megan K Trabert; Leah N Hitchcock; Raoul F Reiser; Brian L Tracy Journal: Motor Control Date: 2015-08-12 Impact factor: 1.422