OBJECTIVE: To study the cardiac functions in Down syndrome children who did not have structural cardiac lesion by conventional and tissue Doppler echocardiography. MATERIALS AND METHODS: A total of 85 children with Down syndrome without anatomic heart disease and 50 normal control children were subjected to the assessment of right and left ventricular functions by both two-dimensional and tissue Doppler echocardiography. RESULTS: Children with Down syndrome had significantly higher left ventricular ejection fraction detected by two-dimensional echocardiography and left ventricular diastolic dysfunction detected by tissue Doppler than observed in the controls. In addition, children with Down syndrome also had right ventricular systolic and diastolic dysfunctions. Children with Down syndrome had significantly higher pulmonary artery systolic pressure than the control children. There was no significant difference in the cardiac functions between children with non-disjunction Down syndrome and those with the translocation type. CONCLUSION: Despite an apparently normal heart, children with Down syndrome may have silent disturbed cardiac functions, which may be detected by two-dimensional or tissue Doppler echocardiography. This may have an important clinical implication, especially before involving Down syndrome children in surgery or strenuous exercise.
OBJECTIVE: To study the cardiac functions in Down syndrome children who did not have structural cardiac lesion by conventional and tissue Doppler echocardiography. MATERIALS AND METHODS: A total of 85 children with Down syndrome without anatomic heart disease and 50 normal control children were subjected to the assessment of right and left ventricular functions by both two-dimensional and tissue Doppler echocardiography. RESULTS:Children with Down syndrome had significantly higher left ventricular ejection fraction detected by two-dimensional echocardiography and left ventricular diastolic dysfunction detected by tissue Doppler than observed in the controls. In addition, children with Down syndrome also had right ventricular systolic and diastolic dysfunctions. Children with Down syndrome had significantly higher pulmonary artery systolic pressure than the control children. There was no significant difference in the cardiac functions between children with non-disjunction Down syndrome and those with the translocation type. CONCLUSION: Despite an apparently normal heart, children with Down syndrome may have silent disturbed cardiac functions, which may be detected by two-dimensional or tissue Doppler echocardiography. This may have an important clinical implication, especially before involving Down syndrome children in surgery or strenuous exercise.
Authors: Mohammed Al-Biltagi; Osama A Tolba; Maher Ahmed Abd ElHafez; Ahmed Abd ElBasset Abo-Elezz; Eman Kamel El Kady; Sahar Mohey El-Din Hazza Journal: Pediatr Nephrol Date: 2016-03-18 Impact factor: 3.714
Authors: Mohammed Al-Biltagi; Osama Abd Rab Elrasoul Tolba; Mohamed Ahmed Rowisha; Amal El-Sayed Mahfouz; Mona Ahmed Elewa Journal: Pediatr Cardiol Date: 2014-10-07 Impact factor: 1.655
Authors: Giulio Calcagni; Camilla Calvieri; Anwar Baban; Francesco Bianco; Rosaria Barracano; Massimo Caputo; Andrea Madrigali; Stefani Silva Kikina; Marco Alfonso Perrone; Maria Cristina Digilio; Marco Pozzi; Aurelio Secinaro; Berardo Sarubbi; Lorenzo Galletti; Maria Giulia Gagliardi; Andrea de Zorzi; Fabrizio Drago; Benedetta Leonardi Journal: J Clin Med Date: 2022-02-06 Impact factor: 4.964