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Literature DB >> 22715258

Adrenalectomy to treat reactivated chronic hepatitis B infection in a patient with a steroid-secreting adrenal tumour.

Abstract

We present a case of reactivation of chronic hepatitis B virus (HBV) infection by a steroid-producing adrenal tumour. The tumour caused a reactivation and subsequent flare of the patients' HBV. The adrenal tumour was treated with an adrenalectomy and as a consequence the patients' transaminitis and viral load fell rapidly without the need for any additional hepatitis B treatment. The role of hepatitis B and steroid priming is discussed and the possible immunological mechanisms that underpin this phenomenon.

Entities: Chemical

Mesh：

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Year: 2011 PMID： 22715258 PMCID： PMC3062063 DOI： 10.1136/bcr.11.2010.3508

Source DB: PubMed Journal: BMJ Case Rep ISSN： 1757-790X

15 in total

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Authors: Don Ganem; Alfred M Prince
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2. A randomised double-blind placebo-controlled trial of prednisolone therapy in HBeAg and HBV DNA positive Chinese patients with chronic active hepatitis B.

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Journal: Ann Intern Med Date: 1986-01 Impact factor: 25.391

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Authors: J Rakela; A G Redeker; B Weliky
Journal: Gastroenterology Date: 1983-05 Impact factor: 22.682

5. Prednisolone priming enhances Th1 response and efficacy of subsequent lamivudine therapy in patients with chronic hepatitis B.

Authors: Y F Liaw; S L Tsai; R N Chien; C T Yeh; C M Chu
Journal: Hepatology Date: 2000-09 Impact factor: 17.425

6. Hepatitis B virus reactivation in lymphoma patients with prior resolved hepatitis B undergoing anticancer therapy with or without rituximab.

Authors: Winnie Yeo; Tung C Chan; Nancy W Y Leung; Wai Y Lam; Frankie K F Mo; Miu Ting Chu; Henry L Y Chan; Edwin P Hui; Kenny I K Lei; Tony S K Mok; Paul K S Chan
Journal: J Clin Oncol Date: 2008-12-15 Impact factor: 44.544

Adrenalectomy to treat reactivated chronic hepatitis B infection in a patient with a steroid-secreting adrenal tumour.

Review 1. Hepatitis B virus infection--natural history and clinical consequences.

2. A randomised double-blind placebo-controlled trial of prednisolone therapy in HBeAg and HBV DNA positive Chinese patients with chronic active hepatitis B.

3. A short course of prednisolone in chronic type B hepatitis. Report of a randomized, double-blind, placebo-controlled trial.

4. Effect of short-term prednisone therapy on aminotransferase levels and hepatitis B virus markers in chronic type B hepatitis.

5. Prednisolone priming enhances Th1 response and efficacy of subsequent lamivudine therapy in patients with chronic hepatitis B.

6. Hepatitis B virus reactivation in lymphoma patients with prior resolved hepatitis B undergoing anticancer therapy with or without rituximab.

7. Submassive liver necrosis in a hepatitis B carrier with Cushing's syndrome.

8. Effects of immunosuppressive therapy on viral markers in chronic active hepatitis B.

9. Glucocorticoid stimulates hepatitis B viral gene expression in cultured human hepatoma cells.

10. Effects of short-term, high-dose prednisone treatment of patients with HBsAg-positive chronic active hepatitis.

1. A case of acute exacerbation of chronic hepatitis C during the course of adrenal Cushing's syndrome.

2. Case reports of latent HBV hepatitis in patients after neurosurgical treatment for hypothalamic and pituitary tumors.