Literature DB >> 22715203

Near fatal intra-operative anaphylaxis to chlorhexidine--is it time to change practice?

R A Khan1, T Kazi, B O'Donohoe.   

Abstract

The authors report a case of a near fatal anaphylactic reaction to chlorhexidine. Increasingly adverse reactions are being reported with the use of chlorhexidine. Serious reactions are related to use on mucous membranes and acceptable alternatives are readily available. Therefore, the fundamental question that must be asked is: is it time to withdraw chlorhexidine preparations used for mucous membranes?

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Year:  2011        PMID： 22715203      PMCID： PMC3062822          DOI： 10.1136/bcr.09.2009.2300

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN： 1757-790X


  8 in total

1.  Anaphylactic shock induced by intraurethral use of chlorhexidine.

Authors:  J Wicki; C Deluze; L Cirafici; J Desmeules
Journal:  Allergy       Date:  1999-07       Impact factor: 13.146

2.  An unexpected cause of an acute hypersensitivity reaction during recovery from anaesthesia.

Authors:  C L Thong; M Lambros; M G Stewart; P C A Kam
Journal:  Anaesth Intensive Care       Date:  2005-08       Impact factor: 1.669

Review 3.  Intraurethral lubricants: a critical literature review and recommendations.

Authors:  Vassilios Tzortzis; Stavros Gravas; Michel M Melekos; Jean J de la Rosette
Journal:  J Endourol       Date:  2009-05       Impact factor: 2.942

Review 4.  Diagnosis and pathogenesis of the anaphylactic and anaphylactoid reactions to anaesthetics.

Authors:  J L Gueant; I Aimone-Gastin; F Namour; D Laroche; A Bellou; M C Laxenaire
Journal:  Clin Exp Allergy       Date:  1998-09       Impact factor: 5.018

5.  Anaphylactic reactions in anaesthetised patients - four cases of chlorhexidine allergy.

Authors:  L H Garvey; J Roed-Petersen; B Husum
Journal:  Acta Anaesthesiol Scand       Date:  2001-11       Impact factor: 2.105

6.  Danish Anaesthesia Allergy Centre - preliminary results.

Authors:  L H Garvey; J Roed-Petersen; T Menné; B Husum
Journal:  Acta Anaesthesiol Scand       Date:  2001-11       Impact factor: 2.105

7.  Two episodes of life-threatening anaphylaxis in the same patient to a chlorhexidine-sulphadiazine-coated central venous catheter.

Authors:  R Stephens; M Mythen; P Kallis; D W Davies; W Egner; A Rickards
Journal:  Br J Anaesth       Date:  2001-08       Impact factor: 9.166

Review 8.  Chlorhexidine anaphylaxis: case report and review of the literature.

Authors:  A B Krautheim; T H M Jermann; A J Bircher
Journal:  Contact Dermatitis       Date:  2004-03       Impact factor: 6.600
  8 in total
  6 in total

1.  Anaphylactic reaction to intraurethral chlorhexidine: sensitisation following previous repeated uneventful administration.

Authors:  J E Dyer; S Nafie; J K Mellon; M A Khan
Journal:  Ann R Coll Surg Engl       Date:  2013-09       Impact factor: 1.891

2.  The danger of chlorhexidine in lignocaine gel: A case report of anaphylaxis during urinary catheterisation.

Authors:  Michael Stewart; Daniel Lenaghan
Journal:  Australas Med J       Date:  2015-09-30

3.  Life-threatening intraoperative anaphylaxis as a result of chlorhexidine present in Instillagel.

Authors:  Joshua Totty; James Forsyth; Anthony Mekako; Ian Chetter
Journal:  BMJ Case Rep       Date:  2017-08-21

4.  A fatal adverse effect of cefazolin administration: severe brain edema in a patient with multiple meningiomas.

Authors:  Sirirat Tribuddharat; Thepakorn Sathitkarnmanee; Amnat Kitkhuandee; Sunchai Theerapongpakdee; Kriangsak Ngamsaengsirisup; Sarinya Chanthawong
Journal:  Drug Healthc Patient Saf       Date:  2016-02-09

Review 5.  Use of Chlorhexidine Preparations in Total Joint Arthroplasty.

Authors:  Jaiben George; Alison K Klika; Carlos A Higuera
Journal:  J Bone Jt Infect       Date:  2017-01-01

6.  Perioperative Anaphylaxis to Chlorhexidine during Surgery and Septoplasty.

Authors:  Ana Paula Teixeira de Abreu; Leonardo Ramos Ribeiro de Oliveira; Ana Flavia Teixeira de Abreu; Evandro Ribeiro de Oliveira; Michele Santos de Melo Ireno; Fernando Monteiro Aarestrup; Matheus Fonseca Aarestrup; Paula Fonseca Aarestrup
Journal:  Case Rep Otolaryngol       Date:  2017-03-19
  6 in total

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