| Literature DB >> 2271514 |
H Kang1, J D Choi, I G Jung, D W Kim, T B Kim, H K Shin, B T Kim, C K Park, J Y Yoo.
Abstract
We report a case of methimazole-induced acute hepatic failure, which occurred 17 weeks after initiation of the drug in a 43-year-old man with hyperthyroidism and hepatitis B surface antigenemia. Postmortem needle autopsy of the liver revealed an established micronodular cirrhosis secondary to hepatitis B with moderate septal/portal inflammation, marked cholestasis and scattered acidophilic bodies. The serum hepatitis B surface antigen (HBsAg) was positive, but reactivation of hepatitis B was unlikely in view of the absence of a serum hepatitis B e antigen (HBeAg) and hepatitis B virus deoxyribonucleic acid (HBV-DNA) and negative stain for HBsAg and hepatitis B core antigen (HBcAg) in the liver tissue.Entities:
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Year: 1990 PMID： 2271514 PMCID： PMC4535001 DOI： 10.3904/kjim.1990.5.1.69
Source DB: PubMed Journal: Korean J Intern Med ISSN： 1226-3303 Impact factor: 2.884