Literature DB >> 22714865

Cartilage development and degeneration: a Wnt Wnt situation.

Katherine Ann Staines1, Vicky Elizabeth Macrae, Colin Farquharson.   

Abstract

The Wnt signaling pathway plays a crucial role in the development and homeostasis of a variety of adult tissues and, as such, is emerging as an important therapeutic target for numerous diseases. Factors involved in the Wnt pathway are expressed throughout limb development and chondrogenesis and have been shown to be critical in joint homeostasis and endochondral ossification. Therefore, in this review, we discuss Wnt regulation of chondrogenic differentiation, hypertrophy and cartilage function. Moreover, we detail the role of the Wnt signaling pathway in cartilage degeneration and its potential to act as a target for therapy in osteoarthritis.
Copyright © 2012 John Wiley & Sons, Ltd.

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Year:  2012        PMID： 22714865     DOI： 10.1002/cbf.2852

Source DB:  PubMed          Journal:  Cell Biochem Funct        ISSN： 0263-6484            Impact factor:   3.685


  22 in total

1.  Gene-gene interactions of the Wnt/β-catenin signaling pathway in knee osteoarthritis.

Authors:  Javier Fernández-Torres; Yessica Zamudio-Cuevas; Alberto López-Reyes; Daniela Garrido-Rodríguez; Karina Martínez-Flores; Carlos Alberto Lozada; José Francisco Muñóz-Valle; Edith Oregon-Romero; Gabriela Angélica Martínez-Nava
Journal:  Mol Biol Rep       Date:  2018-08-06       Impact factor: 2.316

2.  Spatial regulation of gene expression during growth of articular cartilage in juvenile mice.

Authors:  Julian C Lui; Michael Chau; Weiping Chen; Crystal S F Cheung; Jeffrey Hanson; Jaime Rodriguez-Canales; Ola Nilsson; Jeffrey Baron
Journal:  Pediatr Res       Date:  2014-12-18       Impact factor: 3.756

Review 3.  Cartilage to bone transitions in health and disease.

Authors:  K A Staines; A S Pollard; I M McGonnell; C Farquharson; A A Pitsillides
Journal:  J Endocrinol       Date:  2013-09-06       Impact factor: 4.286

4.  Dickkopf-3 is upregulated in osteoarthritis and has a chondroprotective role.

Authors:  S J B Snelling; R K Davidson; T E Swingler; L T T Le; M J Barter; K L Culley; A Price; A J Carr; I M Clark
Journal:  Osteoarthritis Cartilage       Date:  2015-12-12       Impact factor: 6.576

5.  Expression and functional study of extracellular BMP antagonists during the morphogenesis of the digits and their associated connective tissues.

Authors:  Carlos I Lorda-Diez; Juan A Montero; Joaquin Rodriguez-Leon; Juan A Garcia-Porrero; Juan M Hurle
Journal:  PLoS One       Date:  2013-04-03       Impact factor: 3.240

6.  Cytoskeletal Reorganization Drives Mesenchymal Condensation and Regulates Downstream Molecular Signaling.

Authors:  Poulomi Ray; Susan C Chapman
Journal:  PLoS One       Date:  2015-08-03       Impact factor: 3.240

7.  Differentially expressed microRNAs in chondrocytes from distinct regions of developing human cartilage.

Authors:  Audrey McAlinden; Nobish Varghese; Louisa Wirthlin; Li-Wei Chang
Journal:  PLoS One       Date:  2013-09-09       Impact factor: 3.240

Review 8.  The age-related changes in cartilage and osteoarthritis.

Authors:  YongPing Li; XiaoChun Wei; JingMing Zhou; Lei Wei
Journal:  Biomed Res Int       Date:  2013-07-22       Impact factor: 3.411

Review 9.  Signaling pathways in cartilage repair.

Authors:  Erminia Mariani; Lia Pulsatelli; Andrea Facchini
Journal:  Int J Mol Sci       Date:  2014-05-15       Impact factor: 5.923

10.  E11/Podoplanin Protein Stabilization Through Inhibition of the Proteasome Promotes Osteocyte Differentiation in Murine in Vitro Models.

Authors:  Katherine A Staines; Matt Prideaux; Steve Allen; David J Buttle; Andrew A Pitsillides; Colin Farquharson
Journal:  J Cell Physiol       Date:  2015-12-28       Impact factor: 6.384
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