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Literature DB >> 22714590

Dissecting the role of mTOR complexes in cellular senescence.

Manuel Serrano.

Abstract

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2012 PMID： 22714590 PMCID： PMC3383585 DOI： 10.4161/cc.21065

Source DB: PubMed Journal: Cell Cycle ISSN： 1551-4005 Impact factor: 4.534

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9 in total

1. Attenuation of TORC1 signaling delays replicative and oncogenic RAS-induced senescence.

Authors: Marina Kolesnichenko; Lixin Hong; Rong Liao; Peter K Vogt; Peiqing Sun
Journal: Cell Cycle Date: 2012-06-15 Impact factor: 4.534

Review 2. Cellular senescence in cancer and aging.

Authors: Manuel Collado; Maria A Blasco; Manuel Serrano
Journal: Cell Date: 2007-07-27 Impact factor: 41.582

3. Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity.

Authors: Dudley W Lamming; Lan Ye; Pekka Katajisto; Marcus D Goncalves; Maki Saitoh; Deanna M Stevens; James G Davis; Adam B Salmon; Arlan Richardson; Rexford S Ahima; David A Guertin; David M Sabatini; Joseph A Baur
Journal: Science Date: 2012-03-30 Impact factor: 47.728

Review 4. mTOR: from growth signal integration to cancer, diabetes and ageing.

Authors: Roberto Zoncu; Alejo Efeyan; David M Sabatini
Journal: Nat Rev Mol Cell Biol Date: 2010-12-15 Impact factor: 94.444

5. Suppression of replicative senescence by rapamycin in rodent embryonic cells.

Authors: Tatiana V Pospelova; Olga V Leontieva; Tatiana V Bykova; Svetlana G Zubova; Valery A Pospelov; Mikhail V Blagosklonny
Journal: Cell Cycle Date: 2012-06-15 Impact factor: 4.534

6. Rapamycin decelerates cellular senescence.

Authors: Zoya N Demidenko; Svetlana G Zubova; Elena I Bukreeva; Valery A Pospelov; Tatiana V Pospelova; Mikhail V Blagosklonny
Journal: Cell Cycle Date: 2009-06-01 Impact factor: 4.534

7. mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex.

Authors: John T Cunningham; Joseph T Rodgers; Daniel H Arlow; Francisca Vazquez; Vamsi K Mootha; Pere Puigserver
Journal: Nature Date: 2007-11-29 Impact factor: 49.962

8. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice.

Authors: David E Harrison; Randy Strong; Zelton Dave Sharp; James F Nelson; Clinton M Astle; Kevin Flurkey; Nancy L Nadon; J Erby Wilkinson; Krystyna Frenkel; Christy S Carter; Marco Pahor; Martin A Javors; Elizabeth Fernandez; Richard A Miller
Journal: Nature Date: 2009-07-08 Impact factor: 49.962

9. Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.

Authors: Colin Selman; Jennifer M A Tullet; Daniela Wieser; Elaine Irvine; Steven J Lingard; Agharul I Choudhury; Marc Claret; Hind Al-Qassab; Danielle Carmignac; Faruk Ramadani; Angela Woods; Iain C A Robinson; Eugene Schuster; Rachel L Batterham; Sara C Kozma; George Thomas; David Carling; Klaus Okkenhaug; Janet M Thornton; Linda Partridge; David Gems; Dominic J Withers
Journal: Science Date: 2009-10-02 Impact factor: 47.728

9 in total

26 in total

1. Fasting levels of hepatic p-S6 are increased in old mice.

Authors: Olga V Leontieva; Geraldine M Paszkiewicz; Mikhail V Blagosklonny
Journal: Cell Cycle Date: 2014 Impact factor: 4.534

Review 2. Geroconversion: irreversible step to cellular senescence.

Authors: Mikhail V Blagosklonny
Journal: Cell Cycle Date: 2014 Impact factor: 4.534

Review 3. mTOR Signaling from Cellular Senescence to Organismal Aging.

Authors: Shaohua Xu; Ying Cai; Yuehua Wei
Journal: Aging Dis Date: 2013-12-05 Impact factor: 6.745

4. MEK drives cyclin D1 hyperelevation during geroconversion.

Authors: O V Leontieva; Z N Demidenko; M V Blagosklonny
Journal: Cell Death Differ Date: 2013-07-12 Impact factor: 15.828

5. Identification of rictor as a novel substrate of Polo-like kinase 1.

Authors: Tian Shao; Xiaoqi Liu
Journal: Cell Cycle Date: 2015 Impact factor: 4.534

6. Contact inhibition and high cell density deactivate the mammalian target of rapamycin pathway, thus suppressing the senescence program.

Authors: Olga V Leontieva; Zoya N Demidenko; Mikhail V Blagosklonny
Journal: Proc Natl Acad Sci U S A Date: 2014-06-02 Impact factor: 11.205

10. CDK4/6-inhibiting drug substitutes for p21 and p16 in senescence: duration of cell cycle arrest and MTOR activity determine geroconversion.

Authors: Olga V Leontieva; Mikhail V Blagosklonny
Journal: Cell Cycle Date: 2013-08-22 Impact factor: 4.534