OBJECTIVES: To describe predictors of pregnancy and changes in pregnancy incidence among HIV-positive women accessing HIV clinical care. METHODS: Data were obtained through the linkage of two separate studies: the UK Collaborative HIV Cohort study (UK CHIC), a cohort of adults attending 13 large HIV clinics; and the National Study of HIV in Pregnancy and Childhood (NSHPC), a national surveillance study of HIV-positive pregnant women. Pregnancy incidence was measured using the proportion of women in UK CHIC with a pregnancy reported to NSHPC. Generalized estimating equations were used to identify predictors of pregnancy and assess changes in pregnancy incidence in 2000-2009. RESULTS: The number of women accessing care at UK CHIC sites increased as did the number of pregnancies. Older women were less likely to have a pregnancy [adjusted relative rate (aRR) 0.44 per 10 year increment in age, [95% confidence interval (CI) (0.41-0.46)], P < 0.001] as were women with CD4 cell count less than 200 cells/μl compared with CD4 cell count 200-350 cells/μl [aRR 0.65 (0.55-0.77), P < 0.001] and women of white ethnicity compared with women of black African ethnicity [aRR 0.67 (0.57-0.80), P < 0.001]. The likelihood that women had a pregnancy increased over the study period [aRR 1.05 (1.03-1.07), P < 0.001). The rate of change did not significantly differ according to age group, antiretroviral therapy use, CD4 group or ethnicity. CONCLUSION: The pregnancy rate among women accessing HIV clinical care increased in 2000-2009. HIV-positive women with, or planning, a pregnancy require a high level of care and this is likely to continue and increase as more women of older age have pregnancies.
OBJECTIVES: To describe predictors of pregnancy and changes in pregnancy incidence among HIV-positive women accessing HIV clinical care. METHODS: Data were obtained through the linkage of two separate studies: the UK Collaborative HIV Cohort study (UK CHIC), a cohort of adults attending 13 large HIV clinics; and the National Study of HIV in Pregnancy and Childhood (NSHPC), a national surveillance study of HIV-positive pregnant women. Pregnancy incidence was measured using the proportion of women in UK CHIC with a pregnancy reported to NSHPC. Generalized estimating equations were used to identify predictors of pregnancy and assess changes in pregnancy incidence in 2000-2009. RESULTS: The number of women accessing care at UK CHIC sites increased as did the number of pregnancies. Older women were less likely to have a pregnancy [adjusted relative rate (aRR) 0.44 per 10 year increment in age, [95% confidence interval (CI) (0.41-0.46)], P < 0.001] as were women with CD4 cell count less than 200 cells/μl compared with CD4 cell count 200-350 cells/μl [aRR 0.65 (0.55-0.77), P < 0.001] and women of white ethnicity compared with women of black African ethnicity [aRR 0.67 (0.57-0.80), P < 0.001]. The likelihood that women had a pregnancy increased over the study period [aRR 1.05 (1.03-1.07), P < 0.001). The rate of change did not significantly differ according to age group, antiretroviral therapy use, CD4 group or ethnicity. CONCLUSION: The pregnancy rate among women accessing HIV clinical care increased in 2000-2009. HIV-positive women with, or planning, a pregnancy require a high level of care and this is likely to continue and increase as more women of older age have pregnancies.
Authors: B G Gazzard; Jane Anderson; Abdel Babiker; Marta Boffito; Gary Brook; Gary Brough; Duncan Churchill; Ben Cromarty; Satyajit Das; Martin Fisher; Andrew Freedman; Anna Maria Geretti; Margaret Johnson; Saye Khoo; Clifford Leen; Devaki Nair; Barry Peters; Andrew Phillips; Deenan Pillay; Anton Pozniak; John Walsh; Ed Wilkins; Ian Williams; Matthew Williams; Mike Youle Journal: HIV Med Date: 2008-10 Impact factor: 3.180
Authors: D T Baird; J Collins; J Egozcue; L H Evers; L Gianaroli; H Leridon; A Sunde; A Templeton; A Van Steirteghem; J Cohen; P G Crosignani; P Devroey; K Diedrich; B C J M Fauser; L Fraser; A Glasier; I Liebaers; G Mautone; G Penney; B Tarlatzis Journal: Hum Reprod Update Date: 2005-04-14 Impact factor: 15.610
Authors: F J Palella; K M Delaney; A C Moorman; M O Loveless; J Fuhrer; G A Satten; D J Aschman; S D Holmberg Journal: N Engl J Med Date: 1998-03-26 Impact factor: 91.245
Authors: Claire L Townsend; Mario Cortina-Borja; Catherine S Peckham; Annemiek de Ruiter; Hermione Lyall; Pat A Tookey Journal: AIDS Date: 2008-05-11 Impact factor: 4.177
Authors: Howard Minkoff; Ron Hershow; D Heather Watts; Margaret Frederick; Irene Cheng; Ruth Tuomala; Jane Pitt; Carmen D Zorrilla; Hunter Hammill; Samuel K Adeniyi-Jones; Bruce Thompson Journal: Am J Obstet Gynecol Date: 2003-08 Impact factor: 8.661
Authors: Lisa B Haddad; Kristin M Wall; C Christina Mehta; Elizabeth T Golub; Lisa Rahangdale; Mirjam-Colette Kempf; Roksana Karim; Rodney Wright; Howard Minkoff; Mardge Cohen; Seble Kassaye; Deborah Cohan; Igho Ofotokun; Susan E Cohn Journal: Am J Obstet Gynecol Date: 2016-09-15 Impact factor: 8.661
Authors: S Grignolo; R Agnello; D Gerbaldo; C Gotta; C Alicino; F Del Puente; L Taramasso; B Bruzzone; C Gustavino; S Trasino; A DE Maria; G Icardi; C Viscoli; A DI Biagio Journal: Epidemiol Infect Date: 2017-03-22 Impact factor: 4.434
Authors: Susie E Huntington; Loveleen K Bansi; Claire Thorne; Jane Anderson; Marie-Louise Newell; Graham P Taylor; Deenan Pillay; Teresa Hill; Pat A Tookey; Caroline A Sabin Journal: BMC Med Res Methodol Date: 2012-07-28 Impact factor: 4.615
Authors: Susie Huntington; Claire Thorne; Marie-Louise Newell; Jane Anderson; Graham P Taylor; Deenan Pillay; Teresa Hill; Pat A Tookey; Caroline Sabin Journal: AIDS Date: 2015-11 Impact factor: 4.177
Authors: Heun Choi; Moo Hyun Kim; Se Ju Lee; Eun Jin Kim; Woonji Lee; Wooyong Jeong; In Young Jung; Jin Young Ahn; Su Jin Jeong; Nam Su Ku; Ji Hyeon Baek; Young Hwa Choi; Hyo Youl Kim; June Myung Kim; Jun Yong Choi Journal: J Korean Med Sci Date: 2018-10-25 Impact factor: 2.153