INTRODUCTION: The basal ganglia are interconnected with cortical areas involved in behavioural, cognitive and emotional processes, in addition to movement regulation. Little is known about which of these functions are associated with individual basal ganglia substructures. METHODS: Pubmed was searched for literature related to behavioural, cognitive and emotional symptoms associated with focal lesions to basal ganglia structures in humans. RESULTS: Six case-control studies and two case reports were identified as relevant. Lesion sites included the caudate nucleus, putamen and globus pallidus. These were associated with a spectrum of behavioural and cognitive symptoms, including abulia, poor working memory and deficits in emotional recognition. DISCUSSION: It is often difficult to precisely map associations between cognitive, emotional or behavioural functions and particular basal ganglia substructures, due to the non-specific nature of the lesions. However, evidence from lesion studies shows that most symptoms correspond with established non-motor frontal-subcortical circuits.
INTRODUCTION: The basal ganglia are interconnected with cortical areas involved in behavioural, cognitive and emotional processes, in addition to movement regulation. Little is known about which of these functions are associated with individual basal ganglia substructures. METHODS: Pubmed was searched for literature related to behavioural, cognitive and emotional symptoms associated with focal lesions to basal ganglia structures in humans. RESULTS: Six case-control studies and two case reports were identified as relevant. Lesion sites included the caudate nucleus, putamen and globus pallidus. These were associated with a spectrum of behavioural and cognitive symptoms, including abulia, poor working memory and deficits in emotional recognition. DISCUSSION: It is often difficult to precisely map associations between cognitive, emotional or behavioural functions and particular basal ganglia substructures, due to the non-specific nature of the lesions. However, evidence from lesion studies shows that most symptoms correspond with established non-motor frontal-subcortical circuits.
Authors: Anders M Fjell; Markus H Sneve; Andreas B Storsve; Håkon Grydeland; Anastasia Yendiki; Kristine B Walhovd Journal: Cereb Cortex Date: 2015-05-19 Impact factor: 5.357
Authors: Alex Förster; Mansour Al-Zghloul; Hans U Kerl; Johannes Böhme; Bettina Mürle; Christoph Groden Journal: PLoS One Date: 2015-03-24 Impact factor: 3.240
Authors: Claudia C Schmidt; David C Timpert; Isabel Arend; Simone Vossel; Anna Dovern; Jochen Saliger; Hans Karbe; Gereon R Fink; Avishai Henik; Peter H Weiss Journal: Front Hum Neurosci Date: 2018-10-16 Impact factor: 3.169