Literature DB >> 22712625

Detection of congenital heart defects throughout pregnancy; impact of first trimester ultrasound screening for cardiac abnormalities.

Makarios Eleftheriades1, Elsa Tsapakis, Alexandros Sotiriadis, Emmanouil Manolakos, Demetrios Hassiakos, Demetrios Botsis.   

Abstract

OBJECTIVE: To evaluate prospectively the efficacy to screen for congenital heart defects (CHD) during the first trimester nuchal translucency (NT) ultrasound examination by assessing the four chambers' view of fetal heart.
METHODS: Pregnancies that were examined prospectively by ultrasound in the first trimester (11th-14th week), the second (19th-24th week) and third trimester were included in the study. 3774 fetuses were examined and fetal heart was assessed during the NT scan by examining the four chambers view. Detailed echocardiography was performed during the anomaly and growth scans. Diagnosis of congenital heart defects (CHD) was further confirmed by a fetal cardiologist.
RESULTS: The four chambers view was obtained in 99.52% of the cases. CHD were diagnosed in 29 fetuses (0.77%). Thirteen cases (44.8%) were detected during the 11-13 weeks' scan, 14 cases (48.3%) during the anomaly scan, 1 CHD (3.5%) during the third trimester scan and 1 case (3.5%) postpartum.
CONCLUSION: Assessment of the four chambers of fetal heart early in pregnancy was feasible and allowed the detection of 45% of CHD. Additional parameters of fetal cardiac anatomy during the NT scan may further improve the detection rate providing pregnancy management information early in the first trimester.

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Year:  2012        PMID: 22712625     DOI: 10.3109/14767058.2012.703716

Source DB:  PubMed          Journal:  J Matern Fetal Neonatal Med        ISSN: 1476-4954


  9 in total

1.  Effect of miR-20b on Apoptosis, Differentiation, the BMP Signaling Pathway and Mitochondrial Function in the P19 Cell Model of Cardiac Differentiation In Vitro.

Authors:  Shasha Zhu; Xiaoshan Hu; Zhangbin Yu; Yuzhu Peng; Jingai Zhu; Xuehua Liu; Mengmeng Li; Shuping Han; Chun Zhu
Journal:  PLoS One       Date:  2015-04-21       Impact factor: 3.240

2.  Diagnostic value of echocardiography in fetal cardiac malformation and clinical classification.

Authors:  Bo Wang; Jianning Li; Juan Yin
Journal:  Exp Ther Med       Date:  2019-07-03       Impact factor: 2.447

3.  Prevalence and risk factors for congenital heart defects among children in the Multi-Ethnic Yunnan Region of China.

Authors:  Yu Cao; Rongzhong Huang; Ruize Kong; Hongrong Li; Hong Zhang; Yaxiong Li; Liwen Liang; Da Xiong; Shen Han; Liang Zhou; Junyin Guo; Guolin Dai; Mingyao Meng; Hongbo Lou; Zongliu Hou; Lihong Jiang
Journal:  Transl Pediatr       Date:  2022-06

4.  Effectiveness of fetal ultrasound diagnostics in cardiac malformations and association with polyhydramnios and oligohydramnios.

Authors:  Atene Simonyi; Fanni Rebeka Eros; Julia Hajdu; Artur Beke
Journal:  Quant Imaging Med Surg       Date:  2021-07

5.  Fetal heart assessment in the first trimester of pregnancy: influence of crown-rump length and maternal body mass index.

Authors:  David Baptista Silva Pares; Angélia Iara Felipe Lima; Edward Araujo Júnior; Luciano Marcondes Machado Nardozza; Wellington P Martins; Antonio Fernandes Moron
Journal:  Rev Bras Cir Cardiovasc       Date:  2013 Oct-Dec

6.  miR-30c regulates proliferation, apoptosis and differentiation via the Shh signaling pathway in P19 cells.

Authors:  Xuehua Liu; Mengmeng Li; Yuzhu Peng; Xiaoshan Hu; Jing Xu; Shasha Zhu; Zhangbin Yu; Shuping Han
Journal:  Exp Mol Med       Date:  2016-07-29       Impact factor: 8.718

7.  miR-20a regulates proliferation, differentiation and apoptosis in P19 cell model of cardiac differentiation by targeting Smoothened.

Authors:  Feng Ai; Yanwei Zhang; Bangtian Peng
Journal:  Biol Open       Date:  2016-09-15       Impact factor: 2.422

8.  Cardiac axis evaluation as a screening method for detecting cardiac abnormalities in the first trimester of pregnancy.

Authors:  Florina Nela Oşvar; Adrian Claudiu Raţiu; Florica Voiţă-Mekereş; Gheorghe Florin Voiţă; Mihaela Gabriela Bonţea; Mariana Racoviţă; Gabriel Mihai Mekereş; Florian Dorel Bodog
Journal:  Rom J Morphol Embryol       Date:  2020       Impact factor: 1.033

9.  First-trimester ultrasound detection of fetal heart anomalies: systematic review and meta-analysis.

Authors:  J N Karim; E Bradburn; N Roberts; A T Papageorghiou
Journal:  Ultrasound Obstet Gynecol       Date:  2022-01       Impact factor: 8.678

  9 in total

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