Literature DB >> 22711940

Deoxy Derivatives of L-like 5'-Noraristeromycin.

Shante Hinton1, Alecia Riddick, Tesfaye Serbessa.   

Abstract

Several base variations of 2'- and 3'-deoxy derivatives of (+)-4'-deoxy-5'-noraristeromycin have been prepared from enantiomerically pure precursors following standard purine nucleoside construction. These carbocyclic nucleosides were evaluated against hepatitis B virus (HBV) and found to be inactive. No cytotoxicity to the cell line was observed.

Entities:  

Year:  2012        PMID： 22711940      PMCID： PMC3375702          DOI： 10.1016/j.tetlet.2012.01.101

Source DB:  PubMed          Journal:  Tetrahedron Lett        ISSN： 0040-4039            Impact factor:   2.415


  3 in total

1.  Carbocyclic nucleosides as inhibitors of human tumor necrosis factor-alpha production: effects of the stereoisomers of (3-hydroxycyclopentyl)adenines.

Authors:  D R Borcherding; N P Peet; H R Munson; H Zhang; P F Hoffman; T L Bowlin; C K Edwards
Journal:  J Med Chem       Date:  1996-06-21       Impact factor: 7.446

2.  Does the anti-hepatitis B virus activity of (+)-5'-noraristeromycin exist in its 4'-epimer and 4'-deoxygenated derivatives?

Authors:  K L Seley; S W Schneller; B Korba
Journal:  J Med Chem       Date:  1998-06-04       Impact factor: 7.446

3.  Search for new purine- and ribose-modified adenosine analogues as selective agonists and antagonists at adenosine receptors.

Authors:  S M Siddiqi; K A Jacobson; J L Esker; M E Olah; X D Ji; N Melman; K N Tiwari; J A Secrist; S W Schneller; G Cristalli
Journal:  J Med Chem       Date:  1995-03-31       Impact factor: 7.446
  3 in total

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