Literature DB >> 2271161

A sodium-activated potassium current in intact ventricular myocytes isolated from the guinea-pig heart.

G C Rodrigo1, R A Chapman.   

Abstract

A current generated by the Na-activated K channel has been identified in whole cell currents recorded from isolated guinea-pig ventricular myocytes. A partial activation of this current can be achieved near to the physiological range of intracellular sodium concentration [( Na+]i) when it contributes significantly to the global outward current. The decline of the Na-activated K current, the lengthening of the action potential duration and the recovery of [Na+]i occur with a similar time course during recovery from Na loading.

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Year:  1990        PMID： 2271161     DOI： 10.1113/expphysiol.1990.sp003465

Source DB:  PubMed          Journal:  Exp Physiol        ISSN： 0958-0670            Impact factor:   2.969


  11 in total

1.  Potassium inhibition of sodium-activated potassium (K(Na)) channels in guinea-pig ventricular myocytes.

Authors:  X W Niu; R W Meech
Journal:  J Physiol       Date:  2000-07-01       Impact factor: 5.182

2.  The effect of polyamines on KATP channels in guinea-pig ventricular myocytes.

Authors:  X W Niu; R W Meech
Journal:  J Physiol       Date:  1998-04-15       Impact factor: 5.182

3.  Kinetic properties of unitary Na+-dependent K+ channels in inside-out patches from isolated guinea-pig ventricular myocytes.

Authors:  D K Mistry; O Tripathi; R A Chapman
Journal:  J Physiol       Date:  1997-04-01       Impact factor: 5.182

4.  The calcium paradox in isolated guinea-pig ventricular myocytes: effects of membrane potential and intracellular sodium.

Authors:  G C Rodrigo; R A Chapman
Journal:  J Physiol       Date:  1991-03       Impact factor: 5.182

5.  Activation of Slo2.1 channels by niflumic acid.

Authors:  Li Dai; Vivek Garg; Michael C Sanguinetti
Journal:  J Gen Physiol       Date:  2010-03       Impact factor: 4.086

6.  The N-terminal domain of Slack determines the formation and trafficking of Slick/Slack heteromeric sodium-activated potassium channels.

Authors:  Haijun Chen; Jack Kronengold; Yangyang Yan; Valeswara-Rao Gazula; Maile R Brown; Liqun Ma; Gonzalo Ferreira; Youshan Yang; Arin Bhattacharjee; Fred J Sigworth; Larry Salkoff; Leonard K Kaczmarek
Journal:  J Neurosci       Date:  2009-04-29       Impact factor: 6.167

7.  Changes in mitochondrial function induced in isolated guinea-pig ventricular myocytes by calcium overload.

Authors:  K K Minezaki; M S Suleiman; R A Chapman
Journal:  J Physiol       Date:  1994-05-01       Impact factor: 5.182

8.  The Na(+)-dependence of Na(+)-activated K(+)-channels (IK(Na)) in guinea pig ventricular myocytes, is different in excised inside/out patches and cell attached patches.

Authors:  G C Rodrigo
Journal:  Pflugers Arch       Date:  1993-02       Impact factor: 3.657

9.  The role of the Na(+)-Ca2+ exchanger in the rate-dependent increase in contraction in guinea-pig ventricular myocytes.

Authors:  S M Harrison; M R Boyett
Journal:  J Physiol       Date:  1995-02-01       Impact factor: 5.182

Review 10.  The late Na+ current--origin and pathophysiological relevance.

Authors:  Antonio Zaza; Marcella Rocchetti
Journal:  Cardiovasc Drugs Ther       Date:  2013-02       Impact factor: 3.727
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