Literature DB >> 22711555

On being green: can flow chemistry help?

Steven V Ley1.   

Abstract

The principles of Green Chemistry are important but challenging drivers for most modern synthesis programs. To meet these challenges new flow chemistry tools are proving to be very effective by providing improved heat/mass transfer opportunities, lower solvent usage, less waste generation, hazardous compound containment, and the possibility of a 24/7 working regime. This machine-assisted approach can be used to effect repetitive or routine scale-up steps or when combined with reagent and scavenger cartridges, to achieve multi-step synthesis of complex natural products and pharmaceutical agents.
Copyright © 2012 The Japan Chemical Journal Forum and Wiley Periodicals, Inc.

Year:  2012        PMID： 22711555     DOI： 10.1002/tcr.201100041

Source DB:  PubMed          Journal:  Chem Rec        ISSN： 1528-0691            Impact factor:   6.771


  23 in total

1.  Greener and Sustainable Trends in Synthesis of Organics and Nanomaterials.

Authors:  Rajender S Varma
Journal:  ACS Sustain Chem Eng       Date:  2016-11-07       Impact factor: 8.198

2.  C-O bond Formation in a Microfluidic Reactor: High Yield SNAr Substitution of Heteroaryl Chlorides.

Authors:  Mohammad Parvez Alam; Barbara Jagodzinska; Jesus Campagna; Patricia Spilman; Varghese John
Journal:  Tetrahedron Lett       Date:  2016-05-11       Impact factor: 2.415

3.  Development of an Intermittent-Flow Enantioselective Aza-Henry Reaction Using an Arylnitromethane and Homogeneous Brønsted Acid-Base Catalyst with Recycle.

Authors:  Sergey V Tsukanov; Martin D Johnson; Scott A May; Morgan Rosemeyer; Michael A Watkins; Stanley P Kolis; Matthew H Yates; Jeffrey N Johnston
Journal:  Org Process Res Dev       Date:  2016-02-01       Impact factor: 3.317

4.  Rapid and efficient trifluoromethylation of aromatic and heteroaromatic compounds using potassium trifluoroacetate enabled by a flow system.

Authors:  Mao Chen; Stephen L Buchwald
Journal:  Angew Chem Int Ed Engl       Date:  2013-09-05       Impact factor: 15.336

5.  VUT-MK142 : a new cardiomyogenic small molecule promoting the differentiation of pre-cardiac mesoderm into cardiomyocytes.

Authors:  Moumita Koley; Agnes K Mike; Philipp Heher; Xaver Koenig; Michael Schön; Michael Schnürch; Karlheinz Hilber; Georg Weitzer; Marko D Mihovilovic
Journal:  Medchemcomm       Date:  2013-08-01       Impact factor: 3.597

6.  One-step synthesis of pyridines and dihydropyridines in a continuous flow microwave reactor.

Authors:  Mark C Bagley; Vincenzo Fusillo; Robert L Jenkins; M Caterina Lubinu; Christopher Mason
Journal:  Beilstein J Org Chem       Date:  2013-09-30       Impact factor: 2.883

7.  Microflow photochemistry: UVC-induced [2 + 2]-photoadditions to furanone in a microcapillary reactor.

Authors:  Sylvestre Bachollet; Kimitada Terao; Shin Aida; Yasuhiro Nishiyama; Kiyomi Kakiuchi; Michael Oelgemöller
Journal:  Beilstein J Org Chem       Date:  2013-10-04       Impact factor: 2.883

Review 8.  Discovery and resupply of pharmacologically active plant-derived natural products: A review.

Authors:  Atanas G Atanasov; Birgit Waltenberger; Eva-Maria Pferschy-Wenzig; Thomas Linder; Christoph Wawrosch; Pavel Uhrin; Veronika Temml; Limei Wang; Stefan Schwaiger; Elke H Heiss; Judith M Rollinger; Daniela Schuster; Johannes M Breuss; Valery Bochkov; Marko D Mihovilovic; Brigitte Kopp; Rudolf Bauer; Verena M Dirsch; Hermann Stuppner
Journal:  Biotechnol Adv       Date:  2015-08-15       Impact factor: 14.227

9.  Camera-enabled techniques for organic synthesis.

Authors:  Steven V Ley; Richard J Ingham; Matthew O'Brien; Duncan L Browne
Journal:  Beilstein J Org Chem       Date:  2013-05-31       Impact factor: 2.883

Review 10.  Strategic Application of Residence-Time Control in Continuous-Flow Reactors.

Authors:  István M Mándity; Sándor B Ötvös; Ferenc Fülöp
Journal:  ChemistryOpen       Date:  2015-05-20       Impact factor: 2.911
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