OBJECTIVE: To assess whether spontaneous preterm delivery can be predicted from the amount of cell free fetal DNA (cffDNA) as determined by routine fetal RHD genotyping at 25 weeks' gestation. STUDY DESIGN: Cohort study including RhD negative women participating in a routine RHD screening programme. A standard dilution curve was used to quantify the amounts of cffDNA. Values above the 95(th) centile for the study population defined high levels of cffDNA. RESULTS: We found a highly significant association between preterm delivery and cffDNA levels above the 95(th) centile (p = 0.002). Using logistic regression, women with high levels of cffDNA had an odds ratio of 6.3 (95% confidence interval: 1.9-20.9) for preterm delivery before 37 weeks and an odds ratio for delivery before 34 weeks of 16.6 (95% confidence interval: 3.2-84.7) when adjusting for gestational age at sampling, body mass index and previous miscarriages/terminations of pregnancy. CONCLUSION: High levels of cffDNA at 25 weeks are associated with increased risk of spontaneous preterm delivery.
OBJECTIVE: To assess whether spontaneous preterm delivery can be predicted from the amount of cell free fetal DNA (cffDNA) as determined by routine fetal RHD genotyping at 25 weeks' gestation. STUDY DESIGN: Cohort study including RhD negative women participating in a routine RHD screening programme. A standard dilution curve was used to quantify the amounts of cffDNA. Values above the 95(th) centile for the study population defined high levels of cffDNA. RESULTS: We found a highly significant association between preterm delivery and cffDNA levels above the 95(th) centile (p = 0.002). Using logistic regression, women with high levels of cffDNA had an odds ratio of 6.3 (95% confidence interval: 1.9-20.9) for preterm delivery before 37 weeks and an odds ratio for delivery before 34 weeks of 16.6 (95% confidence interval: 3.2-84.7) when adjusting for gestational age at sampling, body mass index and previous miscarriages/terminations of pregnancy. CONCLUSION: High levels of cffDNA at 25 weeks are associated with increased risk of spontaneous preterm delivery.
Authors: Jason C H Tsang; Joaquim S L Vong; Lu Ji; Liona C Y Poon; Peiyong Jiang; Kathy O Lui; Yun-Bi Ni; Ka Fai To; Yvonne K Y Cheng; Rossa W K Chiu; Yuk Ming Dennis Lo Journal: Proc Natl Acad Sci U S A Date: 2017-08-22 Impact factor: 11.205
Authors: Stacy Beck; Irina A Buhimschi; Taryn L Summerfield; William E Ackerman; Ozlem Guzeloglu-Kayisli; Umit A Kayisli; Guomao Zhao; Frederick Schatz; Charles J Lockwood; Catalin S Buhimschi Journal: Am J Reprod Immunol Date: 2019-03-04 Impact factor: 3.886
Authors: Errol R Norwitz; Elizabeth A Bonney; Victoria V Snegovskikh; Michelle A Williams; Mark Phillippe; Joong Shin Park; Vikki M Abrahams Journal: Cold Spring Harb Perspect Med Date: 2015-04-27 Impact factor: 6.915