| Literature DB >> 22711427 |
Justin G Railsback1, Abhishek Singh, Ryan C Pearce, Timothy E McKnight, Ramón Collazo, Zlatko Sitar, Yaroslava G Yingling, Anatoli V Melechko.
Abstract
Weakly charged cationic nanoparticles cause structural changes including local denaturing and compaction to DNA under mild conditions. The charged ligands bind to the phosphate backbone of DNA and the uncharged ligands penetrate the helix and disrupt base pairing. Mobility shifts in electrophoresis, molecular dynamics, and UV-vis spectrophotometry give clues to the details of the interactions.Entities:
Mesh：
Substances：
Year: 2012 PMID： 22711427 DOI： 10.1002/adma.201104891
Source DB: PubMed Journal: Adv Mater ISSN： 0935-9648 Impact factor: 30.849