Literature DB >> 22710798

The PPARγ-FGF1 axis: an unexpected mediator of adipose tissue homeostasis.

Kai Sun1, Philipp E Scherer.   

Abstract

Adipose tissue remodeling is a dynamic process during nutritional fluctuation that plays critical roles in metabolic homeostasis and insulin sensitivity. The process is highly regulated by many factors, including adipokines and cytokines that are locally released within fat pads. In a recent study published in Nature, Jonker and colleagues identified FGF1 as an important mediator that is selectively induced in fat cells by high-fat diet feeding and established the PPARγ-FGF1 axis as a critical pathway that regulates adipose tissue remodeling and ultimately systemic metabolic homeostasis.

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Year:  2012        PMID： 22710798      PMCID： PMC3463264          DOI： 10.1038/cr.2012.94

Source DB:  PubMed          Journal:  Cell Res        ISSN： 1001-0602            Impact factor:   25.617


  16 in total

Review 1.  Structural basis for fibroblast growth factor receptor activation.

Authors:  Moosa Mohammadi; Shaun K Olsen; Omar A Ibrahimi
Journal:  Cytokine Growth Factor Rev       Date:  2005-04       Impact factor: 7.638

Review 2.  Developmental origin of fat: tracking obesity to its source.

Authors:  Stephane Gesta; Yu-Hua Tseng; C Ronald Kahn
Journal:  Cell       Date:  2007-10-19       Impact factor: 41.582

3.  Metabolic dysregulation and adipose tissue fibrosis: role of collagen VI.

Authors:  Tayeba Khan; Eric S Muise; Puneeth Iyengar; Zhao V Wang; Manisha Chandalia; Nicola Abate; Bei B Zhang; Paolo Bonaldo; Streamson Chua; Philipp E Scherer
Journal:  Mol Cell Biol       Date:  2008-12-29       Impact factor: 4.272

Review 4.  Adipose tissue: from lipid storage compartment to endocrine organ.

Authors:  Philipp E Scherer
Journal:  Diabetes       Date:  2006-06       Impact factor: 9.461

5.  Compensation by fibroblast growth factor 1 (FGF1) does not account for the mild phenotypic defects observed in FGF2 null mice.

Authors:  D L Miller; S Ortega; O Bashayan; R Basch; C Basilico
Journal:  Mol Cell Biol       Date:  2000-03       Impact factor: 4.272

6.  Lack of "immunological fitness" during fasting in metabolically challenged animals.

Authors:  Ingrid Wernstedt Asterholm; John McDonald; Pierre-Gilles Blanchard; Madhur Sinha; Qiang Xiao; Jehangir Mistry; Joseph M Rutkowski; Yves Deshaies; Rolf A Brekken; Philipp E Scherer
Journal:  J Lipid Res       Date:  2012-04-13       Impact factor: 5.922

7.  Fibroblast growth factor 1: a key regulator of human adipogenesis.

Authors:  Louise Hutley; Wenda Shurety; Felicity Newell; Ross McGeary; Nicole Pelton; Jennifer Grant; Adrian Herington; Donald Cameron; Jon Whitehead; Johannes Prins
Journal:  Diabetes       Date:  2004-12       Impact factor: 9.461

8.  Sustained low levels of fibroblast growth factor-1 promote persistent microvascular network formation.

Authors:  Shiri Uriel; Eric M Brey; Howard P Greisler
Journal:  Am J Surg       Date:  2006-11       Impact factor: 2.565

9.  Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation.

Authors:  Naomi Hosogai; Atsunori Fukuhara; Kazuya Oshima; Yugo Miyata; Sachiyo Tanaka; Katsumori Segawa; Shigetada Furukawa; Yoshihiro Tochino; Ryutaro Komuro; Morihiro Matsuda; Iichiro Shimomura
Journal:  Diabetes       Date:  2007-04       Impact factor: 9.461

Review 10.  Fat and beyond: the diverse biology of PPARgamma.

Authors:  Peter Tontonoz; Bruce M Spiegelman
Journal:  Annu Rev Biochem       Date:  2008       Impact factor: 23.643
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  6 in total

Review 1.  Molecular mechanisms regulating vascular tone by peroxisome proliferator activated receptor gamma.

Authors:  Pimonrat Ketsawatsomkron; Curt D Sigmund
Journal:  Curr Opin Nephrol Hypertens       Date:  2015-03       Impact factor: 2.894

Review 2.  Metabolic Messengers: fibroblast growth factor 1.

Authors:  Emanuel Gasser; Gencer Sancar; Michael Downes; Ronald M Evans
Journal:  Nat Metab       Date:  2022-06-09

Review 3.  PPARγ signaling and metabolism: the good, the bad and the future.

Authors:  Maryam Ahmadian; Jae Myoung Suh; Nasun Hah; Christopher Liddle; Annette R Atkins; Michael Downes; Ronald M Evans
Journal:  Nat Med       Date:  2013-05-07       Impact factor: 53.440

4.  Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer.

Authors:  Jae Myoung Suh; Johan W Jonker; Maryam Ahmadian; Regina Goetz; Denise Lackey; Olivia Osborn; Zhifeng Huang; Weilin Liu; Eiji Yoshihara; Theo H van Dijk; Rick Havinga; Weiwei Fan; Yun-Qiang Yin; Ruth T Yu; Christopher Liddle; Annette R Atkins; Jerrold M Olefsky; Moosa Mohammadi; Michael Downes; Ronald M Evans
Journal:  Nature       Date:  2014-07-16       Impact factor: 49.962

5.  Acidic fibroblast growth factor attenuates type 2 diabetes-induced demyelination via suppressing oxidative stress damage.

Authors:  Rui Li; Beini Wang; Chengbiao Wu; Duohui Li; Yanqing Wu; Libing Ye; Luxia Ye; Xiongjian Chen; Peifeng Li; Yuan Yuan; Hongyu Zhang; Ling Xie; Xiaokun Li; Jian Xiao; Jian Wang
Journal:  Cell Death Dis       Date:  2021-01-21       Impact factor: 8.469

6.  Comparative Transcriptomic Profiles of Differentiated Adipocytes Provide Insights into Adipogenesis Mechanisms of Subcutaneous and Intramuscular Fat Tissues in Pigs.

Authors:  Pan Zhang; Bo Zhang; Peng Shang; Yu Fu; Ruixue Nie; Yangzom Chamba; Hao Zhang
Journal:  Cells       Date:  2022-01-31       Impact factor: 6.600
  6 in total

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