J Yeh1, J Hastings, A Rao, M A Abbas. 1. Department of Radiation Oncology, Kaiser Permanente, 4950 Sunset Boulevard, 2nd Floor Station B, Los Angeles, CA 90027, USA. jekwon.x.yeh@kp.org
Abstract
BACKGROUND: Squamous cell carcinoma (SCC) of the rectum is a rare disorder. There is currently no effective method as to how best treat patients with this condition. The purpose of this study was to review a single tertiary institution's experience. METHODS: A retrospective chart review was conducted of all patients who presented with documented SCC of the rectum over a 10-year period (2000-2010). During the study period, all patients were offered chemoradiation as an initial treatment modality [a fluorouracil (5-FU)-based regimen in conjunction with mitomycin or cisplatin]. RESULTS: Six patients presented with primary rectal SCC. Mean patient age was 60 years. The majority of patients were female (83 %). The most common presenting symptom was rectal bleeding (67 %). The mean distance from the inferior tumor margin to the anal verge was 6 cm. Two patients (33 %) presented with stage II disease, and 4 (67 %) were stage III. Five patients (83 %) received chemoradiation therapy initially, and 1 patient underwent abdominoperineal resection after refusing chemoradiation. Two additional patients (33 %) underwent salvage surgery. During a mean follow-up of 44 months, 4 patients (66 %) were alive without evidence of disease. CONCLUSIONS: Based on the results of this cases series, chemoradiation as an initial primary therapy appears to be beneficial for patients with primary SCC of the rectum. A 5-FU chemotherapy-based regimen in conjunction with fractionated radiotherapy appears to be effective for local control of the disease.
BACKGROUND:Squamous cell carcinoma (SCC) of the rectum is a rare disorder. There is currently no effective method as to how best treat patients with this condition. The purpose of this study was to review a single tertiary institution's experience. METHODS: A retrospective chart review was conducted of all patients who presented with documented SCC of the rectum over a 10-year period (2000-2010). During the study period, all patients were offered chemoradiation as an initial treatment modality [a fluorouracil (5-FU)-based regimen in conjunction with mitomycin or cisplatin]. RESULTS: Six patients presented with primary rectal SCC. Mean patient age was 60 years. The majority of patients were female (83 %). The most common presenting symptom was rectal bleeding (67 %). The mean distance from the inferior tumor margin to the anal verge was 6 cm. Two patients (33 %) presented with stage II disease, and 4 (67 %) were stage III. Five patients (83 %) received chemoradiation therapy initially, and 1 patient underwent abdominoperineal resection after refusing chemoradiation. Two additional patients (33 %) underwent salvage surgery. During a mean follow-up of 44 months, 4 patients (66 %) were alive without evidence of disease. CONCLUSIONS: Based on the results of this cases series, chemoradiation as an initial primary therapy appears to be beneficial for patients with primary SCC of the rectum. A 5-FU chemotherapy-based regimen in conjunction with fractionated radiotherapy appears to be effective for local control of the disease.
Authors: Glen R Guerra; Cherng H Kong; Satish K Warrier; Andrew C Lynch; Alexander G Heriot; Samuel Y Ngan Journal: World J Gastrointest Surg Date: 2016-03-27
Authors: Max S Chiu; Vivek Verma; Nathan R Bennion; Abhijeet R Bhirud; Jinluan Li; Mary E Charlton; Chandrakanth Are; Chi Lin Journal: Cancer Med Date: 2016-10-26 Impact factor: 4.452
Authors: P Tschann; D Lechner; B Feurstein; B Abendstein; S Dertinger; A Bösl; N Vitlarov; F Offner; I Königsrainer Journal: J Med Case Rep Date: 2020-02-14