SCOPE: Evidence for the benefits of green tea catechins on vascular function is inconsistent, with genotype potentially contributing to the heterogeneity in response. Here, the impact of the catechol-O-methyltransferase (COMT) genotype on vascular function and blood pressure (BP) after green tea extract ingestion are reported. METHODS AND RESULTS:Fifty subjects (n = 25 of the proposed low-activity [AA] and of the high-activity [GG] COMT rs4680 genotype), completed a randomized, double-blind, crossover study. Peripheral arterial tonometry, digital volume pulse (DVP), and BP were assessed at baseline and 90 min after 1.06 g of green tea extract or placebo. A 5.5 h and subsequent 18.5 h urine collection was performed to assess green tea catechin excretion. A genotype × treatment interaction was observed for DVP reflection index (p = 0.014), with green tea extract in the AA COMT group attenuating the increase observed with placebo. A tendency for a greater increase in diastolic BP was evident at 90 min after the green tea extract compared to placebo (p = 0.07). A genotypic effect was observed for urinary methylated epigallocatechin during the first 5.5 h, with the GG COMT group demonstrating a greater concentration (p = 0.049). CONCLUSION: Differences in small vessel tone according to COMT genotype were evident after acute green tea extract.
RCT Entities:
SCOPE: Evidence for the benefits of green tea catechins on vascular function is inconsistent, with genotype potentially contributing to the heterogeneity in response. Here, the impact of the catechol-O-methyltransferase (COMT) genotype on vascular function and blood pressure (BP) after green tea extract ingestion are reported. METHODS AND RESULTS: Fifty subjects (n = 25 of the proposed low-activity [AA] and of the high-activity [GG] COMTrs4680 genotype), completed a randomized, double-blind, crossover study. Peripheral arterial tonometry, digital volume pulse (DVP), and BP were assessed at baseline and 90 min after 1.06 g of green tea extract or placebo. A 5.5 h and subsequent 18.5 h urine collection was performed to assess green tea catechin excretion. A genotype × treatment interaction was observed for DVP reflection index (p = 0.014), with green tea extract in the AA COMT group attenuating the increase observed with placebo. A tendency for a greater increase in diastolic BP was evident at 90 min after the green tea extract compared to placebo (p = 0.07). A genotypic effect was observed for urinary methylated epigallocatechin during the first 5.5 h, with the GG COMT group demonstrating a greater concentration (p = 0.049). CONCLUSION: Differences in small vessel tone according to COMT genotype were evident after acute green tea extract.
Authors: Luc Bruyndonckx; Vicky Y Hoymans; Amaryllis H Van Craenenbroeck; Dirk K Vissers; Christiaan J Vrints; José Ramet; Viviane M Conraads Journal: Oxid Med Cell Longev Date: 2013-04-03 Impact factor: 6.543
Authors: Dragan Milenkovic; Christine Morand; Aedin Cassidy; Aleksandra Konic-Ristic; Francisco Tomás-Barberán; José M Ordovas; Paul Kroon; Raffaele De Caterina; Ana Rodriguez-Mateos Journal: Adv Nutr Date: 2017-07-14 Impact factor: 8.701
Authors: María-Teresa García-Conesa; Karen Chambers; Emilie Combet; Paula Pinto; Mar Garcia-Aloy; Cristina Andrés-Lacueva; Sonia de Pascual-Teresa; Pedro Mena; Alekxandra Konic Ristic; Wendy J Hollands; Paul A Kroon; Ana Rodríguez-Mateos; Geoffrey Istas; Christos A Kontogiorgis; Dilip K Rai; Eileen R Gibney; Christine Morand; Juan Carlos Espín; Antonio González-Sarrías Journal: Int J Mol Sci Date: 2018-02-28 Impact factor: 5.923