BACKGROUND: Oral human papillomavirus (HPV) infection is a cause of oropharyngeal squamous cell carcinoma, yet little is known about the epidemiology and natural history of infection. METHODS: At a baseline and 3-month follow-up visit, 1000 young adults aged 18 to 30 years provided an oral rinse sample and completed a survey assessing demographic and behavioral risk factors. The oral rinse sample was analyzed for 37 types of HPV by use of a multiplex polymerase chain reaction assay. Factors associated with oral HPV detection were analyzed using univariate and bivariate logistic regression. RESULTS: The prevalence of oral HPV infection was 2.4% (95% CI: 1.4-3.4). Ever having consumed alcohol (OR, 0.2; 95% CI: 0.1-0.8), 5 or more lifetime open-mouth kissing (OR, 4.0; 95% CI: 1.1-14.8) or lifetime oral sex (OR, 4.0; 95% CI: 1.3-11.9) partners were associated with infection, controlling for lifetime vaginal sex partners. The incidence rate for oral HPV infection was 5.67 (95% CI: 3.12-8.16) per 1000 person-months. Incident infection was associated in univariate analysis with black race (OR, 4.7; 95% CI: 1.7-13.5) and having open-mouth kissed a new partner in the previous 3 months (OR, 2.6; 95% CI: 1.0-6.4). CONCLUSIONS: This study provides further evidence that oral sexual contact in the form of both oral-oral and oral-genital contact could play a role in the transmission of oral HPV.
BACKGROUND: Oral human papillomavirus (HPV) infection is a cause of oropharyngeal squamous cell carcinoma, yet little is known about the epidemiology and natural history of infection. METHODS: At a baseline and 3-month follow-up visit, 1000 young adults aged 18 to 30 years provided an oral rinse sample and completed a survey assessing demographic and behavioral risk factors. The oral rinse sample was analyzed for 37 types of HPV by use of a multiplex polymerase chain reaction assay. Factors associated with oral HPV detection were analyzed using univariate and bivariate logistic regression. RESULTS: The prevalence of oral HPV infection was 2.4% (95% CI: 1.4-3.4). Ever having consumed alcohol (OR, 0.2; 95% CI: 0.1-0.8), 5 or more lifetime open-mouth kissing (OR, 4.0; 95% CI: 1.1-14.8) or lifetime oral sex (OR, 4.0; 95% CI: 1.3-11.9) partners were associated with infection, controlling for lifetime vaginal sex partners. The incidence rate for oral HPV infection was 5.67 (95% CI: 3.12-8.16) per 1000 person-months. Incident infection was associated in univariate analysis with black race (OR, 4.7; 95% CI: 1.7-13.5) and having open-mouth kissed a new partner in the previous 3 months (OR, 2.6; 95% CI: 1.0-6.4). CONCLUSIONS: This study provides further evidence that oral sexual contact in the form of both oral-oral and oral-genital contact could play a role in the transmission of oral HPV.
Authors: Kristina R Dahlstrom; Ann N Burchell; Agnihotram V Ramanakumar; Allita Rodrigues; Pierre-Paul Tellier; James Hanley; François Coutlée; Eduardo L Franco Journal: Cancer Epidemiol Biomarkers Prev Date: 2014-11-12 Impact factor: 4.254
Authors: R L Winer; C E Huang; S Cherne; J E Stern; M S Butsch Kovacic; P A Mehta; S L Sauter; D A Galloway; R A Katzenellenbogen Journal: Oral Dis Date: 2014-09-18 Impact factor: 3.511
Authors: Krystle A Lang Kuhs; Paula Gonzalez; Linda Struijk; Felipe Castro; Allan Hildesheim; Leen-Jan van Doorn; Ana Cecilia Rodriguez; Mark Schiffman; Wim Quint; Douglas R Lowy; Carolina Porras; Corey Delvecchio; Hormuzd A Katki; Silvia Jimenez; Mahboobeh Safaeian; John Schiller; Diane Solomon; Sholom Wacholder; Rolando Herrero; Aimée R Kreimer Journal: J Infect Dis Date: 2013-09-06 Impact factor: 5.226
Authors: Gypsyamber D'Souza; Neil D Gross; Sara I Pai; Robert Haddad; Karen S Anderson; Shirani Rajan; Jennifer Gerber; Maura L Gillison; Marshall R Posner Journal: J Clin Oncol Date: 2014-04-28 Impact factor: 44.544
Authors: Daniel C Beachler; Elizabeth A Sugar; Joseph B Margolick; Kathleen M Weber; Howard D Strickler; Dorothy J Wiley; Ross D Cranston; Robert D Burk; Howard Minkoff; Susheel Reddy; Weihong Xiao; Yingshi Guo; Maura L Gillison; Gypsyamber D'Souza Journal: Am J Epidemiol Date: 2014-12-04 Impact factor: 4.897