Literature DB >> 22704504

Why is it taking so long to develop clinically competitive stem cell therapies for CNS disorders?

Olle Lindvall1.   

Abstract

The remarkable advancements in basic stem cell research with implications for several central nervous system disorders have so far not been translated into clinically effective therapies. Here I discuss some of the underlying problems and how they could be overcome.
Copyright © 2012 Elsevier Inc. All rights reserved.

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Year:  2012        PMID： 22704504     DOI： 10.1016/j.stem.2012.04.004

Source DB:  PubMed          Journal:  Cell Stem Cell        ISSN： 1875-9777            Impact factor:   24.633


  6 in total

Review 1.  Stem cell therapy: an exercise in patience and prudence.

Authors:  Huan-Ting Lin; Makoto Otsu; Hiromitsu Nakauchi
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2013-01-05       Impact factor: 6.237

2.  Nurr1 blocks the mitogenic effect of FGF-2 and EGF, inducing olfactory bulb neural stem cells to adopt dopaminergic and dopaminergic-GABAergic neuronal phenotypes.

Authors:  Eva Vergaño-Vera; Eva Díaz-Guerra; Eva Rodríguez-Traver; Héctor R Méndez-Gómez; Óscar Solís; Jaime Pignatelli; James Pickel; Sang-Hun Lee; Rosario Moratalla; Carlos Vicario-Abejón
Journal:  Dev Neurobiol       Date:  2014-12-10       Impact factor: 3.964

3.  A preclinical murine model for the early detection of radiation-induced brain injury using magnetic resonance imaging and behavioral tests for learning and memory: with applications for the evaluation of possible stem cell imaging agents and therapies.

Authors:  Ethel J Ngen; Lee Wang; Nishant Gandhi; Yoshinori Kato; Michael Armour; Wenlian Zhu; John Wong; Kathleen L Gabrielson; Dmitri Artemov
Journal:  J Neurooncol       Date:  2016-03-28       Impact factor: 4.130

Review 4.  Making neurons, made easy: The use of Neurogenin-2 in neuronal differentiation.

Authors:  Amy J Hulme; Simon Maksour; Mitchell St-Clair Glover; Sara Miellet; Mirella Dottori
Journal:  Stem Cell Reports       Date:  2021-12-30       Impact factor: 7.765

5.  A 3D in vitro model reveals differences in the astrocyte response elicited by potential stem cell therapies for CNS injury.

Authors:  Emma East; Noémie Johns; Melanie Georgiou; Jon P Golding; A Jane Loughlin; Paul J Kingham; James B Phillips
Journal:  Regen Med       Date:  2013-11       Impact factor: 3.806

6.  Clonal human fetal ventral mesencephalic dopaminergic neuron precursors for cell therapy research.

Authors:  Tania Ramos-Moreno; Javier G Lendínez; María José Pino-Barrio; Araceli Del Arco; Alberto Martínez-Serrano
Journal:  PLoS One       Date:  2012-12-31       Impact factor: 3.240
  6 in total

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