Literature DB >> 22702899

Water-refined solution structure of the human Grb7-SH2 domain in complex with the erbB2 receptor peptide pY1139.

Sally C Pias1, Dennis L Johnson, David E Smith, Barbara A Lyons.   

Abstract

We report a refinement in implicit water of the previously published solution structure of the Grb7-SH2 domain bound to the erbB2 receptor peptide pY1139. Structure quality measures indicate substantial improvement, with residues in the most favored regions of the Ramachandran plot increasing by 14 % and with WHAT IF statistics (Vriend, G. J. Mol. Graph., 1990, 8(1), 52-56) falling closer to expected values for well-refined structures.

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Year:  2012        PMID： 22702899      PMCID： PMC3758482          DOI： 10.2174/092986612801619543

Source DB:  PubMed          Journal:  Protein Pept Lett        ISSN： 0929-8665            Impact factor:   1.890


  30 in total

Review 1.  Grb7 in intracellular signaling and its role in cell regulation.

Authors:  Tang-Long Shen; Jun-Lin Guan
Journal:  Front Biosci       Date:  2004-01-01

2.  Refinement of protein structures in explicit solvent.

Authors:  Jens P Linge; Mark A Williams; Christian A E M Spronk; Alexandre M J J Bonvin; Michael Nilges
Journal:  Proteins       Date:  2003-02-15

3.  WHAT IF: a molecular modeling and drug design program.

Authors:  G Vriend
Journal:  J Mol Graph       Date:  1990-03

4.  Identification of novel non-phosphorylated ligands, which bind selectively to the SH2 domain of Grb7.

Authors:  Stephanie C Pero; Lyn Oligino; Roger J Daly; Amy L Soden; Chen Liu; Peter P Roller; Peng Li; David N Krag
Journal:  J Biol Chem       Date:  2002-01-24       Impact factor: 5.157

5.  Structural basis of binding by cyclic nonphosphorylated peptide antagonists of Grb7 implicated in breast cancer progression.

Authors:  Nigus D Ambaye; Stephanie C Pero; Menachem J Gunzburg; MinYin Yap; Daniel J Clayton; Mark P Del Borgo; Patrick Perlmutter; Marie-Isabel Aguilar; Girja S Shukla; Elena Peletskaya; Michelle M Cookson; David N Krag; Matthew C J Wilce; Jacqueline A Wilce
Journal:  J Mol Biol       Date:  2011-07-23       Impact factor: 5.469

6.  Solution structure of the human Grb7-SH2 domain/erbB2 peptide complex and structural basis for Grb7 binding to ErbB2.

Authors:  Monika Ivancic; Roger J Daly; Barbara A Lyons
Journal:  J Biomol NMR       Date:  2003-11       Impact factor: 2.835

7.  Recognition of a high-affinity phosphotyrosyl peptide by the Src homology-2 domain of p56lck.

Authors:  M J Eck; S E Shoelson; S C Harrison
Journal:  Nature       Date:  1993-03-04       Impact factor: 49.962

8.  Exploring protein native states and large-scale conformational changes with a modified generalized born model.

Authors:  Alexey Onufriev; Donald Bashford; David A Case
Journal:  Proteins       Date:  2004-05-01

9.  Assignment of backbone 1H, 13C, and 15N resonances of human Grb7-SH2 domain in complex with a phosphorylated peptide ligand.

Authors:  Peter J Brescia; Monika Ivancic; Barbara A Lyons
Journal:  J Biomol NMR       Date:  2002-05       Impact factor: 2.835

10.  The SH2 domain protein GRB-7 is co-amplified, overexpressed and in a tight complex with HER2 in breast cancer.

Authors:  D Stein; J Wu; S A Fuqua; C Roonprapunt; V Yajnik; P D'Eustachio; J J Moskow; A M Buchberg; C K Osborne; B Margolis
Journal:  EMBO J       Date:  1994-03-15       Impact factor: 11.598
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